FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1434936574> ?p ?o ?g. }

• W1434936574 endingPage "685" @default.
• W1434936574 startingPage "675" @default.
• W1434936574 abstract "Environmentally induced relapse to cocaine seeking requires the retrieval of context-response-cocaine associative memories. These memories become labile when retrieved and must undergo reconsolidation into long-term memory storage to be maintained. Identification of the molecular underpinnings of cocaine-memory reconsolidation will likely facilitate the development of treatments that mitigate the impact of cocaine memories on relapse vulnerability. Here, we used the rat extinction-reinstatement procedure to test the hypothesis that the Src family of tyrosine kinases (SFK) in the dorsal hippocampus (DH) critically controls contextual cocaine-memory reconsolidation. To this end, we evaluated the effects of bilateral intra-DH microinfusions of the SFK inhibitor, PP2 (62.5 ng per 0.5 μl per hemisphere), following re-exposure to a cocaine-associated (cocaine-memory reactivation) or an unpaired context (no memory reactivation) on subsequent drug context-induced instrumental cocaine-seeking behavior. We also assessed alterations in the phosphorylation state of SFK targets, including GluN2A and GluN2B N-methyl-D-aspartate (NMDA) and GluA2 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits at the putative time of memory restabilization and following PP2 treatment. Finally, we evaluated the effects of intra-DH PEAQX (2.5 μg per 0.5 μl per hemisphere), a GluN2A-subunit-selective NMDAR antagonist, following, or in the absence of, cocaine-memory reactivation on subsequent drug context-induced cocaine-seeking behavior. GluN2A phosphorylation increased in the DH during putative memory restabilization, and intra-DH PP2 treatment inhibited this effect. Furthermore, PP2-as well as PEAQX-attenuated subsequent drug context-induced cocaine-seeking behavior, in a memory reactivation-dependent manner, relative to VEH. These findings suggest that hippocampal SFKs contribute to the long-term stability of cocaine-related memories that underlie contextual stimulus control over cocaine-seeking behavior." @default.
• W1434936574 created "2016-06-24" @default.
• W1434936574 creator A5003871991 @default.
• W1434936574 creator A5005265587 @default.
• W1434936574 creator A5010496598 @default.
• W1434936574 creator A5065426523 @default.
• W1434936574 creator A5085081891 @default.
• W1434936574 creator A5086981091 @default.
• W1434936574 creator A5089625763 @default.
• W1434936574 date "2015-07-23" @default.
• W1434936574 modified "2023-10-14" @default.
• W1434936574 title "Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats" @default.
• W1434936574 cites W1483876599 @default.
• W1434936574 cites W1608785134 @default.
• W1434936574 cites W1869926743 @default.
• W1434936574 cites W1972758800 @default.
• W1434936574 cites W1976806019 @default.
• W1434936574 cites W1981808553 @default.
• W1434936574 cites W1982138808 @default.
• W1434936574 cites W1991449336 @default.
• W1434936574 cites W1992291166 @default.
• W1434936574 cites W1994111283 @default.
• W1434936574 cites W2001217595 @default.
• W1434936574 cites W2007764163 @default.
• W1434936574 cites W2010956619 @default.
• W1434936574 cites W2011293417 @default.
• W1434936574 cites W2011588737 @default.
• W1434936574 cites W2012678641 @default.
• W1434936574 cites W2013517273 @default.
• W1434936574 cites W2015748116 @default.
• W1434936574 cites W2024752098 @default.
• W1434936574 cites W2028594041 @default.
• W1434936574 cites W2029568863 @default.
• W1434936574 cites W2030756376 @default.
• W1434936574 cites W2032596004 @default.
• W1434936574 cites W2037068638 @default.
• W1434936574 cites W2041675118 @default.
• W1434936574 cites W2046355712 @default.
• W1434936574 cites W2063140187 @default.
• W1434936574 cites W2064111585 @default.
• W1434936574 cites W2069342734 @default.
• W1434936574 cites W2074494634 @default.
• W1434936574 cites W2076090607 @default.
• W1434936574 cites W2078758148 @default.
• W1434936574 cites W2087120734 @default.
• W1434936574 cites W2090895449 @default.
• W1434936574 cites W2092921174 @default.
• W1434936574 cites W2093522308 @default.
• W1434936574 cites W2099222699 @default.
• W1434936574 cites W2105460175 @default.
• W1434936574 cites W2112578371 @default.
• W1434936574 cites W2124638528 @default.
• W1434936574 cites W2133859126 @default.
• W1434936574 cites W2142650205 @default.
• W1434936574 cites W2146460558 @default.
• W1434936574 cites W2153497461 @default.
• W1434936574 cites W2154178019 @default.
• W1434936574 cites W2167320436 @default.
• W1434936574 cites W2784028944 @default.
• W1434936574 cites W94931766 @default.
• W1434936574 doi "https://doi.org/10.1038/npp.2015.217" @default.
• W1434936574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4707834" @default.
• W1434936574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26202103" @default.
• W1434936574 hasPublicationYear "2015" @default.
• W1434936574 type Work @default.
• W1434936574 sameAs 1434936574 @default.
• W1434936574 citedByCount "34" @default.
• W1434936574 countsByYear W14349365742016 @default.
• W1434936574 countsByYear W14349365742017 @default.
• W1434936574 countsByYear W14349365742018 @default.
• W1434936574 countsByYear W14349365742019 @default.
• W1434936574 countsByYear W14349365742020 @default.
• W1434936574 countsByYear W14349365742021 @default.
• W1434936574 countsByYear W14349365742022 @default.
• W1434936574 countsByYear W14349365742023 @default.
• W1434936574 crossrefType "journal-article" @default.
• W1434936574 hasAuthorship W1434936574A5003871991 @default.
• W1434936574 hasAuthorship W1434936574A5005265587 @default.
• W1434936574 hasAuthorship W1434936574A5010496598 @default.
• W1434936574 hasAuthorship W1434936574A5065426523 @default.
• W1434936574 hasAuthorship W1434936574A5085081891 @default.
• W1434936574 hasAuthorship W1434936574A5086981091 @default.
• W1434936574 hasAuthorship W1434936574A5089625763 @default.
• W1434936574 hasBestOaLocation W14349365741 @default.
• W1434936574 hasConcept C101991246 @default.
• W1434936574 hasConcept C151730666 @default.
• W1434936574 hasConcept C15744967 @default.
• W1434936574 hasConcept C160268369 @default.
• W1434936574 hasConcept C169760540 @default.
• W1434936574 hasConcept C170493617 @default.
• W1434936574 hasConcept C185592680 @default.
• W1434936574 hasConcept C199289684 @default.
• W1434936574 hasConcept C2779343474 @default.
• W1434936574 hasConcept C2781161787 @default.
• W1434936574 hasConcept C35124327 @default.
• W1434936574 hasConcept C48455012 @default.
• W1434936574 hasConcept C48856860 @default.
• W1434936574 hasConcept C55493867 @default.

• next