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- W143590901 abstract "The chapter discusses conformational forms of the estrogen receptor. The transformation or activation of the estrogen receptor is an estradiol-dependent and temperature-dependent conformational change modifying the receptor's intrinsic activity and sedimentation characteristics. The estrogen-induced transformation of the receptor may be attributed to a change in one or more of the properties of the 4S estrogen-binding protein (EBP): (1) shape, producing a form with hydrodynamic properties that permit faster sedimentation, (2) partial specific volume or density, for example, by phosphorylation or by dissociation of a lipid moiety, or (3) mass, by association with another macromolecule. A change in any of these properties could be provoked by the binding of estradiol to the 4S form of the receptor in association with or independent of the action of an enzyme. The 5S activated or transformed receptor is formed by the association of the 4S protein with another macromolecule, independently of the action of an enzyme." @default.
- W143590901 created "2016-06-24" @default.
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- W143590901 date "1978-01-01" @default.
- W143590901 modified "2023-09-25" @default.
- W143590901 title "Conformational Forms of the Estrogen Receptor" @default.
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- W143590901 doi "https://doi.org/10.1016/b978-0-12-526302-3.50007-1" @default.
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