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- W14361489 abstract "Poly(ADP-ribose)polymerases (PARPs) catalyze a post-transcriptional modification of proteins, consisting in the attachment of mono, oligo or poly ADP-ribose units from NAD+ to specific polar residues of target proteins. The scientific interest in members of this superfamily of enzymes is continuously growing since they have been implicated in a range of diseases including stroke, cardiac ischemia, cancer, inflammation and diabetes. Keywords: Cancer, drug design, poly(ADP-ribose)polymerases, polypharmacology, promiscuity, selective inhibitors, selectivity." @default.
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- W14361489 date "2013-12-03" @default.
- W14361489 modified "2023-09-23" @default.
- W14361489 title "From Polypharmacology to Target Specificity: The Case of PARP Inhibitors" @default.
- W14361489 doi "https://doi.org/10.2174/15680266113136660209" @default.
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