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- W143749470 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) are the most widely used drugsworldwide. More NSAIDs were being produced and manufactured everyday. It was anoverwhelming view that the thought of all NSAIDs were important due to theirtherapeutic actions by inhibiting the production of prostaglandin was challenged by thediscovery that they affect a wide variety of cellular processes along the way. TheNSAIDs piroxicam and mefenamic acid have dissimilar chemical structures, enolicand carboxylic acid respectively, but with the same mode of action for therapeutic uses.They both inhibit prostaglandin synthesis by inhibiting the cyc100xygenase (COX)pathway as of other conventional NSAIDs. However in some cases, they did differwith each other depending on the gravity of their effects on certain aspects.Although the toxicity of piroxicam was well known and documented, mefenamic acidis still not the safest drugs of all. Histologically, mefenamic acid showed a markedtoxicity to the liver and kidney of rats compared to piroxicam. Morphological changes" @default.
- W143749470 created "2016-06-24" @default.
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- W143749470 date "2004-01-01" @default.
- W143749470 modified "2023-09-26" @default.
- W143749470 title "Toxic Effects Of Non-Steroidal Anti-Inflammatory Drugs Piroxicam And Mefenamic Acid And Their Roles As Cancer Chemopreventive Agents" @default.
- W143749470 hasPublicationYear "2004" @default.
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