Matches in SemOpenAlex for { <https://semopenalex.org/work/W143868601> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W143868601 abstract "Estimating the amount of nonspecifically bound ligand is required for the analysis of kinetic data derived from in vivo studies of radioligand-neuroreceptor interactions. Most models assume that nonspecific binding is nonsaturable and rapidly reversible and, therefore, represent nonspecific binding as a constant fraction of the radioligand present in a given tissue compartment. This treatment of nonspecific binding predicts that all brain regions will exhibit similar levels of nonspecific binding subject only to differences in blood flow, and is used to justify the practice of estimating specific binding in receptor-rich regions by subtracting the total radioligand in receptor-poor regions from that found in the receptor-rich region. In reality, however, nonspecific binding is probably heterogeneous in character. Some of it may not exhibit very rapid kinetics relative to specific binding to receptors; some of it may be irreversible. When computer simulations are performed using a model which treats nonspecific binding as a separate compartment with its own kinetic parameters rather than as a constant fraction of the radioligand in extracellular fluid, predicted levels of nonspecific binding differ in receptor-rich and receptor-poor regions, suggesting that using receptor-poor regions to estimate nonspecific binding may not be justified." @default.
- W143868601 created "2016-06-24" @default.
- W143868601 creator A5082637589 @default.
- W143868601 date "1990-02-26" @default.
- W143868601 modified "2023-09-26" @default.
- W143868601 title "Kinetic models for in vivo interaction of radioligand and neuroreceptors" @default.
- W143868601 hasPublicationYear "1990" @default.
- W143868601 type Work @default.
- W143868601 sameAs 143868601 @default.
- W143868601 citedByCount "0" @default.
- W143868601 crossrefType "journal-article" @default.
- W143868601 hasAuthorship W143868601A5082637589 @default.
- W143868601 hasConcept C107824862 @default.
- W143868601 hasConcept C111368507 @default.
- W143868601 hasConcept C116569031 @default.
- W143868601 hasConcept C121332964 @default.
- W143868601 hasConcept C12554922 @default.
- W143868601 hasConcept C127313418 @default.
- W143868601 hasConcept C148898269 @default.
- W143868601 hasConcept C150903083 @default.
- W143868601 hasConcept C152900378 @default.
- W143868601 hasConcept C170493617 @default.
- W143868601 hasConcept C185592680 @default.
- W143868601 hasConcept C203635412 @default.
- W143868601 hasConcept C207001950 @default.
- W143868601 hasConcept C2909005528 @default.
- W143868601 hasConcept C51639874 @default.
- W143868601 hasConcept C55493867 @default.
- W143868601 hasConcept C60592354 @default.
- W143868601 hasConcept C62520636 @default.
- W143868601 hasConcept C67847695 @default.
- W143868601 hasConcept C86803240 @default.
- W143868601 hasConceptScore W143868601C107824862 @default.
- W143868601 hasConceptScore W143868601C111368507 @default.
- W143868601 hasConceptScore W143868601C116569031 @default.
- W143868601 hasConceptScore W143868601C121332964 @default.
- W143868601 hasConceptScore W143868601C12554922 @default.
- W143868601 hasConceptScore W143868601C127313418 @default.
- W143868601 hasConceptScore W143868601C148898269 @default.
- W143868601 hasConceptScore W143868601C150903083 @default.
- W143868601 hasConceptScore W143868601C152900378 @default.
- W143868601 hasConceptScore W143868601C170493617 @default.
- W143868601 hasConceptScore W143868601C185592680 @default.
- W143868601 hasConceptScore W143868601C203635412 @default.
- W143868601 hasConceptScore W143868601C207001950 @default.
- W143868601 hasConceptScore W143868601C2909005528 @default.
- W143868601 hasConceptScore W143868601C51639874 @default.
- W143868601 hasConceptScore W143868601C55493867 @default.
- W143868601 hasConceptScore W143868601C60592354 @default.
- W143868601 hasConceptScore W143868601C62520636 @default.
- W143868601 hasConceptScore W143868601C67847695 @default.
- W143868601 hasConceptScore W143868601C86803240 @default.
- W143868601 hasLocation W1438686011 @default.
- W143868601 hasOpenAccess W143868601 @default.
- W143868601 hasPrimaryLocation W1438686011 @default.
- W143868601 hasRelatedWork W1784780415 @default.
- W143868601 hasRelatedWork W1975041567 @default.
- W143868601 hasRelatedWork W1983829372 @default.
- W143868601 hasRelatedWork W1992406791 @default.
- W143868601 hasRelatedWork W2004273976 @default.
- W143868601 hasRelatedWork W2009071546 @default.
- W143868601 hasRelatedWork W2013839242 @default.
- W143868601 hasRelatedWork W2029537609 @default.
- W143868601 hasRelatedWork W2030090441 @default.
- W143868601 hasRelatedWork W2035168681 @default.
- W143868601 hasRelatedWork W2070753369 @default.
- W143868601 hasRelatedWork W2084697277 @default.
- W143868601 hasRelatedWork W2109244321 @default.
- W143868601 hasRelatedWork W2132856372 @default.
- W143868601 hasRelatedWork W2146130699 @default.
- W143868601 hasRelatedWork W2412048785 @default.
- W143868601 hasRelatedWork W2415296873 @default.
- W143868601 hasRelatedWork W2952833809 @default.
- W143868601 hasRelatedWork W3102882145 @default.
- W143868601 hasRelatedWork W45550680 @default.
- W143868601 isParatext "false" @default.
- W143868601 isRetracted "false" @default.
- W143868601 magId "143868601" @default.
- W143868601 workType "article" @default.