Matches in SemOpenAlex for { <https://semopenalex.org/work/W143872019> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W143872019 abstract "In addition to the role of β-arrestin in AT1 receptor second messenger desensitization, more recent evidence revealed that β-arrestins act as scaffolds for numerous signaling networks, such as the MAPKs. On the other hand, Ang-(1-7) anti-trophic effect in the cardiomyocytes can be mediated by alterations in the MAPKs pathways. In this study we evaluated the effect of AVE0991 (AVE), a nonpeptide Ang-(1-7) mimic, on the signaling pathways involved in the heart hypertrophy induced by DOCA-salt hypertension (DSH). After 4 weeks of induction of DSH, rats received AVE (1mg/kg) by gavage for 2 weeks. AVE attenuated the DSH-induced hypertrophy, as quantified by myocyte diameter measurements (Normotensive rats: 12.97±0.15 μm; DSH: 14.41±0.23 μm; DSH+AVE: 13.39±0.15 μm; n=3 each), without changing the increased blood pressure (tail cuff pletismography). DSH rats showed an increased mRNA expression (real time PCR) of β-arrestin in the left ventricle (LV) (5.96±1.44 A.U. vs 1.01±0.07 A.U. in normotensive rats; p<0.05) that was blocked after AVE (0.84±0.13 A.U.). In addition, AVE induced an increased AT1 receptor expression in the LV (1.95±0.32 vs 1.01±0.09 in normotensive rats; p<0.05). No alteration in cardiac adenylate cyclase expression was observed. These data suggest that Ang-(1-7) may modulate DSH-induced cardiac hypertrophy by altering the β-arrestin pathway. Financial Support: CNPq and INCT" @default.
- W143872019 created "2016-06-24" @default.
- W143872019 creator A5033781234 @default.
- W143872019 creator A5070837996 @default.
- W143872019 creator A5070926183 @default.
- W143872019 creator A5087277690 @default.
- W143872019 creator A5091316283 @default.
- W143872019 date "2010-04-01" @default.
- W143872019 modified "2023-10-14" @default.
- W143872019 title "THE CARDIAC ANTI‐HYPERTROPHIC EFFECT OF AN ORALLY ACTIVE MAS AGONIST IS ASSOCIATED TO A DECREASE IN BETA‐ARRESTIN IN DOCA‐SALT HYPERTENSIVE RATS." @default.
- W143872019 doi "https://doi.org/10.1096/fasebj.24.1_supplement.1040.10" @default.
- W143872019 hasPublicationYear "2010" @default.
- W143872019 type Work @default.
- W143872019 sameAs 143872019 @default.
- W143872019 citedByCount "0" @default.
- W143872019 crossrefType "journal-article" @default.
- W143872019 hasAuthorship W143872019A5033781234 @default.
- W143872019 hasAuthorship W143872019A5070837996 @default.
- W143872019 hasAuthorship W143872019A5070926183 @default.
- W143872019 hasAuthorship W143872019A5087277690 @default.
- W143872019 hasAuthorship W143872019A5091316283 @default.
- W143872019 hasConcept C126322002 @default.
- W143872019 hasConcept C134018914 @default.
- W143872019 hasConcept C167414201 @default.
- W143872019 hasConcept C170493617 @default.
- W143872019 hasConcept C185592680 @default.
- W143872019 hasConcept C2778921608 @default.
- W143872019 hasConcept C2778938600 @default.
- W143872019 hasConcept C71924100 @default.
- W143872019 hasConcept C80631254 @default.
- W143872019 hasConceptScore W143872019C126322002 @default.
- W143872019 hasConceptScore W143872019C134018914 @default.
- W143872019 hasConceptScore W143872019C167414201 @default.
- W143872019 hasConceptScore W143872019C170493617 @default.
- W143872019 hasConceptScore W143872019C185592680 @default.
- W143872019 hasConceptScore W143872019C2778921608 @default.
- W143872019 hasConceptScore W143872019C2778938600 @default.
- W143872019 hasConceptScore W143872019C71924100 @default.
- W143872019 hasConceptScore W143872019C80631254 @default.
- W143872019 hasFunder F4320322025 @default.
- W143872019 hasIssue "S1" @default.
- W143872019 hasLocation W1438720191 @default.
- W143872019 hasOpenAccess W143872019 @default.
- W143872019 hasPrimaryLocation W1438720191 @default.
- W143872019 hasRelatedWork W2027913950 @default.
- W143872019 hasRelatedWork W2034583712 @default.
- W143872019 hasRelatedWork W2050423574 @default.
- W143872019 hasRelatedWork W2058205365 @default.
- W143872019 hasRelatedWork W2063619316 @default.
- W143872019 hasRelatedWork W2074821979 @default.
- W143872019 hasRelatedWork W2080063393 @default.
- W143872019 hasRelatedWork W2101411396 @default.
- W143872019 hasRelatedWork W2169225653 @default.
- W143872019 hasRelatedWork W2748952813 @default.
- W143872019 hasVolume "24" @default.
- W143872019 isParatext "false" @default.
- W143872019 isRetracted "false" @default.
- W143872019 magId "143872019" @default.
- W143872019 workType "article" @default.