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• W143875483 abstract "Manganese superoxide dismutase (MnSOD), is a mitochondria-localized antioxidant enzyme that scavenges superoxide anions generated in the respiratory chains, has been known to play an important role in the radioprotection, and function as a tumor suppressor gene in many types of cancer. Sirtuin 3 (Sirt3) is a mitochondrial NADdependent deacetylase that regulates mitochondrial oxidative metabolism, MnSOD activity, and tumorigenesis. The current study was designed to examine the role of MnSOD and Sirt3 in regulating mitochondrial metabolism and steady-state levels of O2 •in thymocyte responses to ionizing radiation (IR) and lymphomagenesis. Loss of MnSOD in thymocytes resulted in the decreased levels of viability when mice were exposed to 0.1 or 1 Gy Cs radiation. In contrast, loss of Sirt3 did not affect thymocyte radiosensitivity or radiation-induced superoxide levels when mice were exposed to a single dose of Cs radiation (0.1 or 1 Gy). Interestingly, the Sirt3 thymocytes demonstrated a compromised ability to induce an adaptive response following whole body exposure to a 0.1 Gy dose of Cs radiation when challenged 4 h later with a 1.5 Gy dose of Cs radiation. Of note, both Sirt3 and MnSOD thymocytes did not demonstrate increased T cell lymphoma in C57BL/6 mice at 15-18 months following low dose (0.1 Gy or 1 Gy) radiation exposure to low linear energy transfer (LET) Cs or high LET 300 MeV/n Silicon (67 kev/μM) irradiation. Interestingly, the loss of Sirt3 in Bax overexpressing transgenic thymocytes did cause significant alterations in mitochondrial oxidative metabolism including increased levels of superoxide, increased mitochondrial membrane potential, and increased oxygen consumption, as well as decreased levels of MnSOD activity and decreased steady-state levels of ATP. Sirt3 was also found to be upregulated in Lck-Bax transgenic pre-malignant thymocytes, and downregulation of Sirt3 was noted in lymphomas from Lck-Bax mice. Furthermore, a significant acceleration of thymic lymphoma development was observed in Lck-Bax transgenic animals lacking Sirt3. In" @default.
• W143875483 created "2016-06-24" @default.
• W143875483 creator A5037624612 @default.
• W143875483 date "2018-11-29" @default.
• W143875483 modified "2023-10-11" @default.
• W143875483 title "The role of MnSOD and sirtuin 3 in thymocyte responses to radiation and lymphomagenesis" @default.
• W143875483 cites W1492322138 @default.
• W143875483 cites W1494360569 @default.
• W143875483 cites W1523213544 @default.
• W143875483 cites W1537667391 @default.
• W143875483 cites W1559173033 @default.
• W143875483 cites W1565127991 @default.
• W143875483 cites W1580575515 @default.
• W143875483 cites W1588685480 @default.
• W143875483 cites W1623897355 @default.
• W143875483 cites W1650754258 @default.
• W143875483 cites W1821918060 @default.
• W143875483 cites W1845131886 @default.
• W143875483 cites W1952402412 @default.
• W143875483 cites W1964298889 @default.
• W143875483 cites W1965935659 @default.
• W143875483 cites W1966571906 @default.
• W143875483 cites W1968221397 @default.
• W143875483 cites W1968816740 @default.
• W143875483 cites W1970060454 @default.
• W143875483 cites W1970990976 @default.
• W143875483 cites W1972673389 @default.
• W143875483 cites W1972748438 @default.
• W143875483 cites W1976423026 @default.
• W143875483 cites W1976689488 @default.
• W143875483 cites W1977320782 @default.
• W143875483 cites W1979815517 @default.
• W143875483 cites W1984373476 @default.
• W143875483 cites W1984397718 @default.
• W143875483 cites W1984943603 @default.
• W143875483 cites W1985446280 @default.
• W143875483 cites W1994019126 @default.
• W143875483 cites W1995631432 @default.
• W143875483 cites W1996073244 @default.
• W143875483 cites W1996595762 @default.
• W143875483 cites W1997055993 @default.
• W143875483 cites W1997757821 @default.
• W143875483 cites W2000326742 @default.
• W143875483 cites W2001613105 @default.
• W143875483 cites W2001850061 @default.
• W143875483 cites W2002817805 @default.
• W143875483 cites W2004601117 @default.
• W143875483 cites W2004747812 @default.
• W143875483 cites W2005374900 @default.
• W143875483 cites W2008993505 @default.
• W143875483 cites W2009180579 @default.
• W143875483 cites W2009772673 @default.
• W143875483 cites W2010336485 @default.
• W143875483 cites W2012946032 @default.
• W143875483 cites W2013841882 @default.
• W143875483 cites W2013866322 @default.
• W143875483 cites W2014447062 @default.
• W143875483 cites W2019332869 @default.
• W143875483 cites W2019343963 @default.
• W143875483 cites W2019597681 @default.
• W143875483 cites W2021081717 @default.
• W143875483 cites W2022976570 @default.
• W143875483 cites W2023627397 @default.
• W143875483 cites W2024674412 @default.
• W143875483 cites W2024825178 @default.
• W143875483 cites W2024994588 @default.
• W143875483 cites W2026699471 @default.
• W143875483 cites W2028614554 @default.
• W143875483 cites W2029313521 @default.
• W143875483 cites W2030079903 @default.
• W143875483 cites W2032917789 @default.
• W143875483 cites W2033559853 @default.
• W143875483 cites W2034269086 @default.
• W143875483 cites W2034773856 @default.
• W143875483 cites W2035496100 @default.
• W143875483 cites W2035543709 @default.
• W143875483 cites W2036974544 @default.
• W143875483 cites W2037723157 @default.
• W143875483 cites W2039283984 @default.
• W143875483 cites W2039374791 @default.
• W143875483 cites W2040625305 @default.
• W143875483 cites W2042710774 @default.
• W143875483 cites W2042716686 @default.
• W143875483 cites W2043549608 @default.
• W143875483 cites W2043567121 @default.
• W143875483 cites W2043932983 @default.
• W143875483 cites W2044011898 @default.
• W143875483 cites W2046242068 @default.
• W143875483 cites W2049266192 @default.
• W143875483 cites W2050357506 @default.
• W143875483 cites W2050454564 @default.
• W143875483 cites W2050897300 @default.
• W143875483 cites W2051181260 @default.
• W143875483 cites W2052543023 @default.
• W143875483 cites W2052751736 @default.
• W143875483 cites W2056174640 @default.
• W143875483 cites W2058821788 @default.
• W143875483 cites W2059760067 @default.
• W143875483 cites W2063337621 @default.
• W143875483 cites W2063511083 @default.

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