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• W1438861743 abstract "Publisher Summary The protein tyrosine kinases (PTKs) are a thematic protein family––built around a highly conserved domain capable of phosphorylating protein substrates on tyrosine residues. Members of this family are made up as a mosaic of sensory, regulatory, and effector domains. Members of the receptor tyrosine kinases (RTK) family hold a number of structural features, such as an extracellular ligand-binding domain, a single transmembrane domain, a single protein tyrosine kinase domain, and one regulatory domain, which serves to reign in the catalytic activity of the PTK domain. This chapter discusses the structure of RTK, its developmental mutants, and tumorigenesis. The expression patterns of many human, murine, and Drosophila RTKs have been determined by Northern analysis of mRNAs from adult tissues. RTKs have been detected at elevated levels in particular types of tumor. RTKs may be overexpressed or inappropriately expressed in a ligand-independent activated form to transform cells. The chapter also reviews several aspects of the oncogenicity of members of the RTK family and the signal transduction pathways downstream of the activated receptor. The structural alterations associated with the acquisition of oncogenicity by members of RTK class of proteins are also focused in the chapter." @default.
• W1438861743 created "2016-06-24" @default.
• W1438861743 creator A5085604730 @default.
• W1438861743 date "1992-01-01" @default.
• W1438861743 modified "2023-10-14" @default.
• W1438861743 title "Protein Tyrosine Kinase Growth Factor Receptors and their Ligands in Development, Differentiation, and Cancer" @default.
• W1438861743 cites W1479319703 @default.
• W1438861743 cites W1484741568 @default.
• W1438861743 cites W1484947470 @default.
• W1438861743 cites W1510487353 @default.
• W1438861743 cites W1512958442 @default.
• W1438861743 cites W1518877053 @default.
• W1438861743 cites W1565014919 @default.
• W1438861743 cites W1582158832 @default.
• W1438861743 cites W1598732592 @default.
• W1438861743 cites W1654852813 @default.
• W1438861743 cites W172183759 @default.
• W1438861743 cites W1752312133 @default.
• W1438861743 cites W1757346030 @default.
• W1438861743 cites W1768148184 @default.
• W1438861743 cites W1780824832 @default.
• W1438861743 cites W1808352992 @default.
• W1438861743 cites W1851380627 @default.
• W1438861743 cites W1863695472 @default.
• W1438861743 cites W1881900550 @default.
• W1438861743 cites W1907677934 @default.
• W1438861743 cites W1931843124 @default.
• W1438861743 cites W1947523625 @default.
• W1438861743 cites W1964629878 @default.
• W1438861743 cites W1964822816 @default.
• W1438861743 cites W1965372133 @default.
• W1438861743 cites W1966973502 @default.
• W1438861743 cites W1968446194 @default.
• W1438861743 cites W1971972894 @default.
• W1438861743 cites W1973033337 @default.
• W1438861743 cites W1976321898 @default.
• W1438861743 cites W1977242691 @default.
• W1438861743 cites W1982727248 @default.
• W1438861743 cites W1982745900 @default.
• W1438861743 cites W1987413856 @default.
• W1438861743 cites W198779817 @default.
• W1438861743 cites W1991631964 @default.
• W1438861743 cites W1992401642 @default.
• W1438861743 cites W1995337883 @default.
• W1438861743 cites W1997000340 @default.
• W1438861743 cites W1999200731 @default.
• W1438861743 cites W2000079550 @default.
• W1438861743 cites W2000572318 @default.
• W1438861743 cites W2000727723 @default.
• W1438861743 cites W2000911264 @default.
• W1438861743 cites W2002085601 @default.
• W1438861743 cites W2005280521 @default.
• W1438861743 cites W2005529016 @default.
• W1438861743 cites W2006348933 @default.
• W1438861743 cites W2006846396 @default.
• W1438861743 cites W2007206244 @default.
• W1438861743 cites W2012141473 @default.
• W1438861743 cites W2012768706 @default.
• W1438861743 cites W2015313106 @default.
• W1438861743 cites W2015467176 @default.
• W1438861743 cites W2016188929 @default.
• W1438861743 cites W2017995506 @default.
• W1438861743 cites W2018171716 @default.
• W1438861743 cites W2019926749 @default.
• W1438861743 cites W2020244870 @default.
• W1438861743 cites W2020257412 @default.
• W1438861743 cites W2020411245 @default.
• W1438861743 cites W2020501605 @default.
• W1438861743 cites W2024798441 @default.
• W1438861743 cites W2025825805 @default.
• W1438861743 cites W2027737655 @default.
• W1438861743 cites W2028377603 @default.
• W1438861743 cites W2028387622 @default.
• W1438861743 cites W2029503020 @default.
• W1438861743 cites W2030156849 @default.
• W1438861743 cites W2031234072 @default.
• W1438861743 cites W2032359283 @default.
• W1438861743 cites W2035595923 @default.
• W1438861743 cites W2036395676 @default.
• W1438861743 cites W2036895735 @default.
• W1438861743 cites W2037010084 @default.
• W1438861743 cites W2037695813 @default.
• W1438861743 cites W2037831105 @default.
• W1438861743 cites W2041190857 @default.
• W1438861743 cites W2045593483 @default.
• W1438861743 cites W2046841536 @default.
• W1438861743 cites W2048625423 @default.
• W1438861743 cites W2048905477 @default.
• W1438861743 cites W2054042846 @default.
• W1438861743 cites W2055787036 @default.
• W1438861743 cites W2057301899 @default.
• W1438861743 cites W2057409901 @default.
• W1438861743 cites W2058406380 @default.
• W1438861743 cites W2059163294 @default.
• W1438861743 cites W2059944708 @default.
• W1438861743 cites W2060271381 @default.
• W1438861743 cites W2063422026 @default.
• W1438861743 cites W2063436204 @default.
• W1438861743 cites W2064378491 @default.
• W1438861743 cites W2064934740 @default.

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