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• W143951735 abstract "The neuropeptide arginine vasopressin (AVP) is one of the mammalian antidiuretic hormones. It is synthesized as a high-molecular weight precursor molecule in cell bodies of the supraoptic and paraventricular nuclei of the hypothalamus, and carried by axonal transport to terminals in the neurohypophysis, where it is stored (41). The usual physiological stimulus for vasopressin release is an increase in plasma osmolality, sensed by cells in the hypothalamus. The peptide released in response to this stimulus acts on the kidney to promote water retention, thus completing a feedback loop serving to regulate plasma osmolality. Under conditions of severe hemorrhage or other reduction of plasma volume, large amounts of vasopressin can be released into the circulation, and vasopressin can also act on vascular smooth muscle to produce a pressor effect. These pathways for vasopressin synthesis and release define the classical model of a neurosecretory system. However, over the past several years evidence has accumulated for the existence of vasopressin-containing neurons that extend into various areas of the brain (2,5,7,8,44)." @default.
• W143951735 created "2016-06-24" @default.
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• W143951735 date "1989-01-01" @default.
• W143951735 modified "2023-09-23" @default.
• W143951735 title "Vasopressin and Ethanol Tolerance: Postulated Mechanism for Neuroadaptation" @default.
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• W143951735 doi "https://doi.org/10.1007/978-1-4612-4514-8_10" @default.
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