Matches in SemOpenAlex for { <https://semopenalex.org/work/W1439845598> ?p ?o ?g. }
- W1439845598 abstract "Publisher Summary In this chapter, recent developments in atherosclerosis regression, high density lipoproteins established, and newer antihyperlipidemic agents are outlined, and recent work on the metabolic disposition of some of the lipid lowering drugs is discussed. Finally, the advances in therapeutic control of cholesterol gallstones are summarized in this chapter. A decrease in serum cholesterol levels results in a decrease not only in the lipid content but also in the size of experimentally induced atherosclerotic lesions. Evidence of this association in man has been demonstrated by coronary angiography. The study of the control of serum lipid levels and their relationship to coronary heart disease (CHD) has evolved through several phases. Initially, the emphasis was on serum cholesterol levels, stimulated no doubt by the availability of methods to measure cholesterol. Later, it became apparent that examination of the control of lipid transport is necessary for the understanding and management of lipid disorders. The bile acid sequestering anion exchange resins (cholestyramine, colestipol and polidexide) continue to show utility in lowering serum cholesterol levels in Type II hyperlipoproteinemia. The chapter also reviews the pharmacologic and therapeutic properties of probucol. Probucol lowers plasma cholesterol levels without affecting triglyceride levels. The antiatherogenic action of the hypoglycemic biguanide metformin appears to be associated more with alterations in apolipoprotein structure and composition than with lipid lowering effects. Bezafibrate, an analogue of clofibrate, had similar effects on serum lipids and lipoproteins as did clofibrate. Combined administration of clofibrate and diosgenin to rats produced combined effects on serum lipoproteins." @default.
- W1439845598 created "2016-06-24" @default.
- W1439845598 creator A5087927269 @default.
- W1439845598 date "1979-01-01" @default.
- W1439845598 modified "2023-09-25" @default.
- W1439845598 title "Chapter 19 Disorders of Lipid Metabolism" @default.
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