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- W144008631 endingPage "346" @default.
- W144008631 startingPage "321" @default.
- W144008631 abstract "This chapter explores acute tolerance in the nervous system and the molecular mechanisms that underlie it. The chapter focuses on a number of molecules within the nervous system, including N-Methyl-D-aspartate receptors (NMDA receptors), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors), type A γ-aminobutyric acid receptors (GABA-A receptors), and large conductance voltage- and calcium-activated potassium channels (BK channels). The BK channel has been widely studied both functionally and with respect to molecular tolerance, and we focus on this channel protein as a primary example, describing a series of published data from our and other laboratories that illustrate a variety of mechanisms via which molecular tolerance to alcohol is accomplished. We have arbitrarily adopted an organizational schema for this chapter that investigates the mechanisms of molecular tolerance at three levels from the most basic level of molecular biology, including DNA and mRNA, through the protein level." @default.
- W144008631 created "2016-06-24" @default.
- W144008631 creator A5067734027 @default.
- W144008631 creator A5072557642 @default.
- W144008631 date "2014-01-01" @default.
- W144008631 modified "2023-09-25" @default.
- W144008631 title "Molecular Mechanisms Underlying the Development of Functional and Behavioral Tolerance to Alcohol" @default.
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