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- W1440145475 abstract "Publisher Summary This chapter discusses the nature of ultrasonic energy, its mode of propagation, and physical properties. Descriptions of the key biophysical phenomena that are observed when ultrasound interacts with biological tissues are also covered. Skin permeabilization by ultrasound involves combining low-frequency ultrasound with another enhancer to develop synergistic enhancement strategies. Sodium lauryl sulfate has already been identified as an effective chemical enhancer that acts in this manner when combined with ultrasound. It is useful to carry on searching for other such synergistic compounds. Other types of physical enhancers such as electroporation and iontophoresis are also available. Low-frequency sonophoresis has considerable potential for facilitating needle-free vaccinations and immunizations. Transcutaneous immunization provides contact with the skin's immune system via densely concentrated antigen-presenting Langerhans cells. These cells induce T-cell-mediated immune reactions against numerous antigens. For this technique to be practical, the vaccine, which is usually a large molecule, must penetrate the stratum corneum. Low-frequency ultrasound could be used to permeabilize the stratum corneum to a vaccine as well as a complementary adjuvant. Another exciting potential application lies in the realm of topical genomic therapy. The concept is that sonophoretic treatment allows either a gene–vector complex or oligonucleotides to penetrate into the stratum corneum. The target could be either cutaneous cells or, alternatively, systemic circulation. Highly debilitating monogenic cutaneous disorders, such as epidermolysis bullosa, might one day be treated in this way." @default.
- W1440145475 created "2016-06-24" @default.
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- W1440145475 date "2010-01-01" @default.
- W1440145475 modified "2023-10-18" @default.
- W1440145475 title "Ultrasound-based Technology for Skin Barrier Permeabilization" @default.
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- W1440145475 doi "https://doi.org/10.1016/b978-0-8155-2025-2.10005-8" @default.
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