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- W1440303032 abstract "Proc Amer Assoc Cancer Res, Volume 45, 20041292 Epidermal growth factor receptor (EGFR) expression is a common feature of solid tumours and in many cancer types is associated with a poor prognosis. There is evidence suggesting a link between EGFR expression and the radiation response of a tumour. A link between the intrinsic radiosensitivity of primary human tumours and EGFR expression has not been established. A retrospective study was carried out in 125 patients with locally advanced carcinoma of cervix. The patients had all received radiotherapy alone with curative intent. Pretreatment tumour EGFR expression was examined immunohistochemically and analysed using a scoring system of 0, 1, 2 and 3 for increasing intensity of staining. Tumour radiosensitivity was measured using a clonogenic assay as surviving fraction at 2 Gy (SF2). Tumours with high EGFR expression (n=8; median SF2=0.38) were significantly more radioresistant than tumours with low EGFR expression (n=59; median SF2=0.61) with p=0.048 (Mann-Whitney U-test). In 125 patients tumour EGFR expression was a significant prognostic factor for disease-free survival (p=0.0085), local recurrence-free survival (0.0082), but not metastasis-free survival (p=0.078). This study has shown that high levels of EGFR expression are associated with the intrinsic radioresistance of human tumours. High EGFR expression may act as a marker of radioresistance and might aid the identification of patients with a high risk of local failure following radiotherapy." @default.
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- W1440303032 date "2004-04-01" @default.
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- W1440303032 title "The relationship between EGFR expression and intrinsic radiosensitivity in carcinoma of the cervix" @default.
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