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- W1440336427 abstract "This chapter discusses the peptide regulation of mast-cell function. The ability of peptides of immune, neural, and endocrine origin to affect mast-cell function is now well established. Once viewed with only passing pharmacological interest and believed to be of little physiological relevance, peptides are now recognized as important regulators of mast-cell secretion, growth, and development. Besides, they are now believed to participate with mast cells in allergic disease, in bronchial asthma, and in various states of inflammation. The ability of peptides to modulate mast-cell function could contribute to the suggested roles for mast cells in the control of the microenvironment and in tissue growth and repair. Mast cells have been studied because of their prominent role in the reactions of immediate-type hypersensitivity. A widely distributed fixed tissue cell, the mast cell, is particularly prevalent in organs with a high percentage of connective tissue and is most numerous in the skin and in the linings of the respiratory, gastrointestinal, and reproductive tracts, tissues that interface with the external environment. In these various locations, mast cells are frequently found in close proximity to small blood vessels and nerves. This prominence of the mast cell in tissues that interface with the external world is strategic to its role as the sentinel cell of the inflammatory response." @default.
- W1440336427 created "2016-06-24" @default.
- W1440336427 creator A5084263835 @default.
- W1440336427 date "1990-01-01" @default.
- W1440336427 modified "2023-09-23" @default.
- W1440336427 title "4 Peptide Regulation of Mast-Cell Function" @default.
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