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- W144036770 endingPage "156" @default.
- W144036770 startingPage "95" @default.
- W144036770 abstract "Filopodia are finger-like cellular protrusions found throughout the metazoan kingdom and perform fundamental cellular functions during development and cell migration. Neurons exhibit a wide variety of extremely complex morphologies. In the nervous system, filopodia underlie many major morphogenetic events. Filopodia have roles spanning the initiation and guidance of neuronal processes, axons and dendrites to the formation of synaptic connections. This chapter addresses the mechanisms of the formation and dynamics of neuronal filopodia. Some of the major lessons learned from the study of neuronal filopodia are (1) there are multiple mechanisms that can regulate filopodia in a context-dependent manner, (2) that filopodia are specialized subcellular domains, (3) that filopodia exhibit dynamic membrane recycling which also controls aspects of filopodial dynamics, (4) that neuronal filopodia contain machinery for the orchestration of the actin and microtubule cytoskeleton, and (5) localized protein synthesis contributes to neuronal filopodial dynamics." @default.
- W144036770 created "2016-06-24" @default.
- W144036770 creator A5075088638 @default.
- W144036770 date "2013-01-01" @default.
- W144036770 modified "2023-10-12" @default.
- W144036770 title "Mechanisms Underlying the Initiation and Dynamics of Neuronal Filopodia" @default.
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