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• W144063601 abstract "Publisher SummaryThis chapter focuses on the various neuropsychiatric manifestations that have been described in presence of antiphospholipid antibodies (APAs). APAs are a group of antibodies that have been associated with thrombosis, thrombocytopenia, multiple spontaneous abortions, livedo reticularis, psychiatric manifestations, and various other nonthrombotic neurological syndromes. The antiphospholipid syndrome (APS) is categorized as secondary if it occurs in an individual with systemic lupus erythematosus (SLE) or another collagen vascular disease and primary in the absence of SLE. Catastrophic APS, which is an accelerated form of APS that leads to multi-organ failure, has been associated with CNS involvement in a large number of patients. The most common neurologic complications are ischemic stroke and transient ischemic attacks, both of which are believed to be caused by thrombosis or thromboembolism without vasculitis. Cognitive deficits associated to primary or secondary APS can vary from mild deficits to vascular dementia. In addition, the catastrophic APS can present with an acute organic brain syndrome characterized by fulminant encephalopathy. The wide diversity of potential etiologies combined with numerous clinical manifestations makes any psychiatric diagnosis secondary to APS very difficult. In addition, behavioral complications, such as psychosis and mood disorders, may manifest independently of cognitive loss, although in many cases the two occur concurrently." @default.
• W144063601 created "2016-06-24" @default.
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• W144063601 date "2002-01-01" @default.
• W144063601 modified "2023-09-25" @default.
• W144063601 title "Neurologic Manifestations in the Antiphospholipid Syndrome" @default.
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• W144063601 doi "https://doi.org/10.1016/b978-044450987-1/50019-x" @default.
• W144063601 hasPublicationYear "2002" @default.
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