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- W144064430 abstract "To evaluate the reliability of the ACTH test as a means for detection of late onset congenital adrenal hyperplasia (CAH) and discriminating it from polycystic ovary syndrome (PCOS), by repeating the test after 6 months of cyproterone acetate and ethinyl E 2 treatment. Follow-up comparison study. Reproductive Endocrinology in an university tertiary center. Thirty-one young women with hirsutism, oligoamenorrhea, and acne, 21 of them detected as late onset CAH, and 10 as non-late onset CAH (PCOS). Cyproterone acetate and ethinyl E 2 treatment for ≥ 6 months. The ACTH test, before and after 6 months of cyproterone acetate + ethinyl E 2 treatment, and human leukocyte antigen (HLA) typing. The ACTH test interpretation correlated to HLA typing. By repeating the ACTH stimulation test in the 31 women (after cyproterone acetate + ethinyl E 2 administration), we found a diminution in the rate of accumulation of 17α-hydroxy-progesterone (Δ17-OHP) + P, in all 21-hydroxylase late onset CAH cases. As a result of treatment with cyproterone acetate + ethinyl E 2 , a decrease in the accumulation rate of 17-OHP + P, below the discriminative value for late onset CAH (6.5 ng/dL per minute), was noted among 12 of 21 women defined primarily as late onset CAH. Among the nine other women, a decrease in the accumulation rate of 17-OHP + P was noted, however not < 6.5 ng/dL per minute. The interpretation of Δ17-OHP + P for the diagnosis of late onset CAH may be too sensitive as to the correct clinical diagnosis of late onset CAH. By repeating the ACTH test after 6 months of treatment with cyproterone acetate + ethinyl E 2 , specificity and accuracy may be improved." @default.
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- W144064430 date "1996-10-01" @default.
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- W144064430 title "Overdiagnosis of 21-hydroxylase late onset congenital adrenal hyperplasia: correlation of corticotropin test and human leukocyte antigen typing" @default.
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- W144064430 doi "https://doi.org/10.1016/s0015-0282(16)58567-7" @default.
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