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• W144161244 abstract "The effect of oral contraceptives (OCs) on the hemostatic system was compared in 131 OC users and 30 controls. The estrogen doses ranged between 30-50 mcg of ethinyl estradiol or mestranol. Assays reflecting clotting (fibrinopeptide A) platelet activation (platelet factor 4 and beta thromboglobulin) and vascular enthelial damage (fibronectin) were within normal limits and did not differ between cases and controls. On the other hand plasminogen prekallikrein and protein C hemostatic parameters (protective against clotting) were above the normal range in OC users (120% higher) and significantly higher than in matched controls. Further analysis indicated that antithrombin levels were significantly lower in women with a family history of thromboembolism while fibrinogen and fibronectin levels were significantly higher in obese OC users; however there were no manifestations of activated hemostasis in either group. Overall these findings provide no evidence for the claim that OC use is associated with hypercoagulability. However it is recommended that a family history of thromboembolism should be included among the questions routinely asked before OC use is initiated. It is hoped that future research will improve the ability to detect the small number of OC users who will suffer thromboembolism." @default.
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• W144161244 date "1988-04-01" @default.
• W144161244 modified "2023-09-24" @default.
• W144161244 title "Oral contraceptives and the hemostatic system." @default.
• W144161244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3353050" @default.
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