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- W1442667305 abstract "This chapter describes the application of cell-fusion techniques to induce amniotic fluid cells to express special functions and for complementation analysis. Amniotic fluid cells obtained from second-trimester pregnancies have been used to diagnose chromosomal abnormalities, inherited enzyme defects, and hemoglobin abnormalities. Established human lines might also be acceptable provided the gene products in question differ between the amniocyte and the immortal human parent. Nonsenescing or established lines are also likely to be most successful because the hybrid may require several generations of proliferation before analysis. The parental line should be karyotypically stable and not generate hybrids with rapid loss or rearrangement of the human genome. The rodent line should be hyperdiploid. This trait may not be essential to the activation of the human genome. Another gene of potential interest for prenatal diagnosis is phenylalanine hydroxylase. A deficiency of this liver-specific enzyme is associated with phenylketonuria, an autosomal recessive disorder that leads to severe mental retardation unless treated soon after birth by dietary restriction of phenylalanine. Controls for the detection of activated proteins would include hybrids with normal amniocytes assayed simultaneously." @default.
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- W1442667305 date "1982-01-01" @default.
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- W1442667305 title "Chapter 11. Application of Cell-Fusion Techniques to Induce Amniotic Fluid Cells to Express Special Functions and for Complementation Analysis" @default.
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- W1442667305 doi "https://doi.org/10.1016/s0091-679x(08)61371-0" @default.
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