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• W1442696325 abstract "Abstract Drug resistance in tuberculosis (TB) is a global problem and both developed as well as under developed parts of the world are predisposed to drug resistant TB. Multiple drug resistant–TB (MDR-TB) designates the very strain of the pathogen which is resistant to at least two primary anti-TB drugs isoniazid and rifampicin. This strain after acquiring a further bacillary resistance to any second line injectable drug and any of the fluoroquinolones is termed as extensively drug resistant TB (XDR-TB). The present review is endeavored to recapitulate the contemporary state of multidrug resistance in TB, the pathophysiology and recent developments for a rapid and reliable detection of the infection and management of MDR-TB. The challenge of MDR-TB management must be embarked on by skilled doctors at operational BCL-3 laboratory facilities where all allied services for the in-vitro sensitivity testing of mycobacteria are available because it includes extended treatment with costly second–line drugs containing meticulous toxicity. Even more dreaded are some newly emerging TB strains namely XDR-TB which is resistant to many more anti-TB agents (such as isonicotinic acid hydrazide and rifampicin plus second line injectable streptomycin, amikacin and kanamycin). Newer discovery of novel anti-TB drugs through recent research regarding the management of drug resistant tuberculosis would help avert and eradicate MDR-TB as well as XDR-TB. For shortening of the TB–treatment regimen, a few drugs, especially gatifloxacin and moxifloxacin, are being tested, while PA-824, OPC-67683 and TMC-207 are also being studied for both drug resistant and drug susceptible disease. Given the past global trends in MDR-TB, if aggressive preventive and management strategies are not implemented against it, XDR-TB would emerge to a larger extent which would severely cripple global control efforts of TB. However, very recently a newly discovered drug bedoquinoline is demonstrating strong promise towards containment of XDR-TB." @default.
• W1442696325 created "2016-06-24" @default.
• W1442696325 creator A5045902524 @default.
• W1442696325 creator A5059143636 @default.
• W1442696325 creator A5062232870 @default.
• W1442696325 creator A5065725031 @default.
• W1442696325 date "2015-09-01" @default.
• W1442696325 modified "2023-09-22" @default.
• W1442696325 title "An update on pathogenesis and management of tuberculosis with special reference to drug resistance" @default.
• W1442696325 cites W104815003 @default.
• W1442696325 cites W112699339 @default.
• W1442696325 cites W130187559 @default.
• W1442696325 cites W1438513550 @default.
• W1442696325 cites W145717416 @default.
• W1442696325 cites W1544107224 @default.
• W1442696325 cites W1564916751 @default.
• W1442696325 cites W1612172060 @default.
• W1442696325 cites W1764742906 @default.
• W1442696325 cites W1793129498 @default.
• W1442696325 cites W1843621014 @default.
• W1442696325 cites W1954576959 @default.
• W1442696325 cites W1966243392 @default.
• W1442696325 cites W1971551618 @default.
• W1442696325 cites W1972770301 @default.
• W1442696325 cites W1972862720 @default.
• W1442696325 cites W1978610764 @default.
• W1442696325 cites W1982168502 @default.
• W1442696325 cites W1996194136 @default.
• W1442696325 cites W1996794817 @default.
• W1442696325 cites W1997107662 @default.
• W1442696325 cites W1999728092 @default.
• W1442696325 cites W2001079134 @default.
• W1442696325 cites W2001506399 @default.
• W1442696325 cites W2002991152 @default.
• W1442696325 cites W2002996942 @default.
• W1442696325 cites W2003550623 @default.
• W1442696325 cites W2003947050 @default.
• W1442696325 cites W2010483931 @default.
• W1442696325 cites W2013755313 @default.
• W1442696325 cites W2025852196 @default.
• W1442696325 cites W2026766410 @default.
• W1442696325 cites W2031232438 @default.
• W1442696325 cites W2033290625 @default.
• W1442696325 cites W2036317207 @default.
• W1442696325 cites W2038538152 @default.
• W1442696325 cites W2039734648 @default.
• W1442696325 cites W2044276087 @default.
• W1442696325 cites W2046059283 @default.
• W1442696325 cites W2050662476 @default.
• W1442696325 cites W2050876704 @default.
• W1442696325 cites W2058925610 @default.
• W1442696325 cites W2060662281 @default.
• W1442696325 cites W2062279016 @default.
• W1442696325 cites W2065466742 @default.
• W1442696325 cites W2067387627 @default.
• W1442696325 cites W2071339586 @default.
• W1442696325 cites W2071973715 @default.
• W1442696325 cites W2073938972 @default.
• W1442696325 cites W2075000963 @default.
• W1442696325 cites W2082064308 @default.
• W1442696325 cites W2088268037 @default.
• W1442696325 cites W2090542083 @default.
• W1442696325 cites W2090891753 @default.
• W1442696325 cites W2093205717 @default.
• W1442696325 cites W2098693527 @default.
• W1442696325 cites W2099338126 @default.
• W1442696325 cites W2099674057 @default.
• W1442696325 cites W2099929652 @default.
• W1442696325 cites W2100179766 @default.
• W1442696325 cites W2100687489 @default.
• W1442696325 cites W2101812662 @default.
• W1442696325 cites W2102354280 @default.
• W1442696325 cites W2105954379 @default.
• W1442696325 cites W2108374918 @default.
• W1442696325 cites W2108490970 @default.
• W1442696325 cites W2108960489 @default.
• W1442696325 cites W2113918973 @default.
• W1442696325 cites W2114257703 @default.
• W1442696325 cites W2114438836 @default.
• W1442696325 cites W2114568396 @default.
• W1442696325 cites W2114581075 @default.
• W1442696325 cites W2119603196 @default.
• W1442696325 cites W2120027073 @default.
• W1442696325 cites W2121906637 @default.
• W1442696325 cites W2122135250 @default.
• W1442696325 cites W2122379835 @default.
• W1442696325 cites W2135193803 @default.
• W1442696325 cites W2137386154 @default.
• W1442696325 cites W2139352203 @default.
• W1442696325 cites W2139372735 @default.
• W1442696325 cites W2140154490 @default.
• W1442696325 cites W2142107244 @default.
• W1442696325 cites W2143537616 @default.
• W1442696325 cites W2143853155 @default.
• W1442696325 cites W2144134116 @default.
• W1442696325 cites W2144386728 @default.
• W1442696325 cites W2145316802 @default.
• W1442696325 cites W2146173158 @default.
• W1442696325 cites W2146349024 @default.
• W1442696325 cites W2146416817 @default.

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