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• W144342318 startingPage "235" @default.
• W144342318 abstract "The brain-derived neurotrophic factor (BDNF) was first isolated from pig brain. In vivo, BDNF increases the survival of embryonic neurons in the dorsal root ganglia and nodose ganglia, as well as developing and axotomized motoneurons. It also prevents the degeneration of medial septal cholinergic neurons following fimbria transection. BDNF null-mutated mice develop several sensory deficits; however, no obvious defects were seen for motoneurons or central dopaminergic neurons. In both the rat embryo and the adult animal, NT-4 mRNA expression appears to be more general than expression of mRNAs for the other three neurotrophins. Low but detectable levels of NT-4 mRNA were seen at all the developmental stages in all the 12 non-neural tissues analyzed. In the pituitary and submandibular glands, the expression level of NT-4 mRNA was the highest in the one-week-old animal and the amount declined progressively during the onset of development." @default.
• W144342318 created "2016-06-24" @default.
• W144342318 creator A5014174188 @default.
• W144342318 creator A5015919609 @default.
• W144342318 creator A5036728095 @default.
• W144342318 date "1995-01-01" @default.
• W144342318 modified "2023-10-06" @default.
• W144342318 title "Structure and Regulation of BDNF and NT-4 Genes" @default.
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