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- W144356434 abstract "Reaction mechanisms involved in the induction of mammary gland neoplasia in rats by exposure to ionizing radiation are discussed. Doses of 400 r total- body Co/sup 60 gamma radiation resulted within 10 to 12 mo in mammary gland neoplasia in a large percentage of exposed rats. Many of the animals developed tumors in more than one mammary gland, and as many as 10 neoplasms were observed in a single animal. The neoplasms were generally of 4 types. The effects of hormones, dose, partial-body shielding fractionated dosage, and the possible virus etiology of neoplasms are discussed. Data indicate that a two-stage, or more, mechanism is involved and that radiation acts as the initiating factor and the ovarian hormones act as a promoting substance. The radiation data are consistent with the no-threshold, proportionality hypothesis of radioinduced neoplasia. (C.R.)" @default.
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- W144356434 date "1964-01-01" @default.
- W144356434 modified "2023-09-27" @default.
- W144356434 title "RADIATION-INDUCED MAMMARY GLAND NEOPLASIA IN THE RAT" @default.
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- W144356434 doi "https://doi.org/10.1016/b978-0-08-010525-3.50033-1" @default.
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