Matches in SemOpenAlex for { <https://semopenalex.org/work/W144403882> ?p ?o ?g. }
- W144403882 endingPage "46" @default.
- W144403882 startingPage "337" @default.
- W144403882 abstract "Physiological and pathological bone resorption is mediated by osteoclasts, multinucleated cells which are formed by the fusion of monocyte / macrophage precursors. The canonical pathway of osteoclast formation requires the presence of the receptor activator for NFkappaB ligand (RANKL) and macrophage colony stimulating factor (M-CSF). Non-canonical pathways of osteoclast formation have been described in which cytokines / growth factors can substitute for RANKL or M-CSF to induce osteoclast formation. Substitutes for RANKL include LIGHT, TNFalpha and interleukins 6, 11 and 8. M-CSF substitutes include vascular endothelial growth factor (VEGF), placental growth factor (PlGF), FLt-3 ligand and hepatocyte growth factor (HGF). These growth factors can also influence canonical (RANKL / M-CSF-induced) osteoclast formation. Both canonical and non-canonical pathways of osteoclast formation play a role in the formation of osteolytic lesions where there is increased osteoclast formation and activity, such as in giant cell tumour of bone." @default.
- W144403882 created "2016-06-24" @default.
- W144403882 creator A5018195879 @default.
- W144403882 creator A5084862046 @default.
- W144403882 date "2009-03-01" @default.
- W144403882 modified "2023-09-23" @default.
- W144403882 title "Canonical and non-canonical pathways of osteoclast formation." @default.
- W144403882 cites W1245164586 @default.
- W144403882 cites W1493048246 @default.
- W144403882 cites W1534645474 @default.
- W144403882 cites W1586698168 @default.
- W144403882 cites W1600542667 @default.
- W144403882 cites W1622426808 @default.
- W144403882 cites W1964066819 @default.
- W144403882 cites W1964846497 @default.
- W144403882 cites W1966677577 @default.
- W144403882 cites W1967722049 @default.
- W144403882 cites W1972739162 @default.
- W144403882 cites W1977830503 @default.
- W144403882 cites W1981884992 @default.
- W144403882 cites W1983215193 @default.
- W144403882 cites W1986784478 @default.
- W144403882 cites W1988699576 @default.
- W144403882 cites W1991414324 @default.
- W144403882 cites W1991762596 @default.
- W144403882 cites W1991824786 @default.
- W144403882 cites W1994001076 @default.
- W144403882 cites W1994403682 @default.
- W144403882 cites W1996348498 @default.
- W144403882 cites W1998823367 @default.
- W144403882 cites W1999796063 @default.
- W144403882 cites W2000170431 @default.
- W144403882 cites W2000624726 @default.
- W144403882 cites W2000757945 @default.
- W144403882 cites W2000983409 @default.
- W144403882 cites W2002063061 @default.
- W144403882 cites W2003733256 @default.
- W144403882 cites W2008467935 @default.
- W144403882 cites W2009079495 @default.
- W144403882 cites W2009781710 @default.
- W144403882 cites W2014208932 @default.
- W144403882 cites W2014225480 @default.
- W144403882 cites W2017986457 @default.
- W144403882 cites W2018638504 @default.
- W144403882 cites W2018795955 @default.
- W144403882 cites W2019146941 @default.
- W144403882 cites W2020765879 @default.
- W144403882 cites W2021821328 @default.
- W144403882 cites W2025086383 @default.
- W144403882 cites W2026185771 @default.
- W144403882 cites W2027741344 @default.
- W144403882 cites W2029654331 @default.
- W144403882 cites W2032336191 @default.
- W144403882 cites W2034671653 @default.
- W144403882 cites W2035086883 @default.
- W144403882 cites W2036257249 @default.
- W144403882 cites W2036368043 @default.
- W144403882 cites W2037602068 @default.
- W144403882 cites W2041138285 @default.
- W144403882 cites W2044229396 @default.
- W144403882 cites W2045165255 @default.
- W144403882 cites W2045910040 @default.
- W144403882 cites W2047829802 @default.
- W144403882 cites W2051790573 @default.
- W144403882 cites W2053972816 @default.
- W144403882 cites W2055332987 @default.
- W144403882 cites W2055420849 @default.
- W144403882 cites W2058945521 @default.
- W144403882 cites W2060081258 @default.
- W144403882 cites W2060870390 @default.
- W144403882 cites W2063048904 @default.
- W144403882 cites W2063647573 @default.
- W144403882 cites W2065297127 @default.
- W144403882 cites W2066574904 @default.
- W144403882 cites W2068319541 @default.
- W144403882 cites W2071693303 @default.
- W144403882 cites W2073614902 @default.
- W144403882 cites W2076263545 @default.
- W144403882 cites W2076984034 @default.
- W144403882 cites W2077779110 @default.
- W144403882 cites W2078019320 @default.
- W144403882 cites W2079736991 @default.
- W144403882 cites W2080330659 @default.
- W144403882 cites W2083037103 @default.
- W144403882 cites W2088796820 @default.
- W144403882 cites W2093956992 @default.
- W144403882 cites W2094492848 @default.
- W144403882 cites W2094554815 @default.
- W144403882 cites W2096884368 @default.
- W144403882 cites W2098478027 @default.
- W144403882 cites W2102460328 @default.
- W144403882 cites W2105010528 @default.
- W144403882 cites W2109608328 @default.
- W144403882 cites W2110097720 @default.
- W144403882 cites W2111967805 @default.
- W144403882 cites W2117524665 @default.
- W144403882 cites W2117963070 @default.
- W144403882 cites W2118176175 @default.