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- W1444180541 abstract "Since the discovery of HHV-6, attempts have been made to determine what role it plays in the progressive destruction of the immune system by the HIV-1 virus. Studies have been equally disappointing in helping to define the role of HHV-6 in HIV-1 infections. Studies have shown that HHV-6 and HIV-1 could infect the same cell. HHV-6-infected cells could be dually infected with HIV-1. HIV-1 accelerates the cytopathic effect produced by HHV-6 in chimpanzee cells. Conflicting results have shown that at relatively low levels of infectivity of both HHV-6 and HIV-1, HHV-6 suppresses HIV-1 expression. It was also felt that intracellular changes induced by HHV-6 might act to inhibit the production of HIV-1 in dual infection. This suggests that inhibitory effect of HHV-6 on HIV-1 might be mediated by an immediate–early or an early gene product of HHV-6, which is suppressed by ganciclovir." @default.
- W1444180541 created "2016-06-24" @default.
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- W1444180541 date "1992-01-01" @default.
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- W1444180541 title "Chapter 19 Human herpesvirus-6 and HIV-1 infection" @default.
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- W1444180541 doi "https://doi.org/10.1016/s0168-7069(08)70070-3" @default.
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