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- W1444335506 abstract "This chapter discusses the mechanism of bile-acid biosynthesis in mammalian liver. Generally, the most important pathway for the metabolism and excretion of cholesterol in mammals is the formation of bile acids. The major primary bile acids, cholic and chenodeoxycholic acid, are formed from cholesterol in the liver and secreted with bile to the intestine. The reactions involved are saturation of the double bond, epimerization of the 3β-hydroxyl group, introduction of hydroxyl groups into the 7α and 12α positions, oxidation of the C27, side chain to a C24-carboxylic acid, and conjugation with taurine or glycine. The sequence of these reactions has been studied extensively and the major pathways have been defined with a high degree of certainty in rat and man. After the secretion of the primary bile acids with bile to the intestine, microorganisms may transform them into secondary bile acids, such as deoxycholic and lithocholic acid. The major part of all bile acids in the intestine is absorbed and returns to the liver via the portal blood. Only a small fraction is excreted in the feces. The bile acids returning to the liver in the enterohepatic circulation may be further metabolized before they are reconjugated and re-excreted into the bile. The conversion of cholesterol into bile acids represents the most obvious example of the high capacity of the liver to convert lipid-soluble material into excretable water-soluble products." @default.
- W1444335506 created "2016-06-24" @default.
- W1444335506 creator A5062519764 @default.
- W1444335506 date "1985-01-01" @default.
- W1444335506 modified "2023-10-04" @default.
- W1444335506 title "Chapter 9 Mechanism of bile acid biosynthesis in mammalian liver" @default.
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