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- W144463400 endingPage "193" @default.
- W144463400 startingPage "173" @default.
- W144463400 abstract "Nerve growth factor is a target-derived neurotrophic factor acting on sympathetic and neural crest-derived sensory neurons in the peripheral nervous system (PNS) and some populations of cholinergic neurons in the central nervous system (CNS; Levi-Montalcini and Hamburger, 1951; 1953; Levi-Montalcini, 1987; Hefti and Weiner, 1986; Thoenen and Barde, 1980). Nerve growth factor isolated from mouse submaxillary glands has a sedimentation coefficient of 7S which lacks biological activity (Varon et al.,1972; Stach and Shooter, 1980) and is made up of two alphas, one beta, and two gamma subunits (α2βγ2). The biologically active form is the β-subunit, a homodimer made up of two identical polypeptides. Each chain contains three intrachain disulfide bonds which are crucial for biological activity since the reduction of these bonds abolishes biological activity (Greene and Shooter, 1980; Perez-Polo et al., 1990; Fahnestock, 1991). There are significant homologies in the amino acid sequence of the α -and γ-subunits (Greene et al.,1969; Thomas et al., 1981; Evans and Richards, 1985). The γ-subunit of 7S NGF (γ-NGF) is an arginine- or lysine-specific trypsin-like serine proteinase in the kallikrein gene family (Thomas et al., 1981; Evans and Richards, 1985; Evans et al., 1987). The γ-NGF has been postulated to function during the processing of the β-NGF precursor and may participate in cellular migration or tissue remodeling. The γ-NGF can also cleave recombinant single chain urokinase-type plasminogen activators which might be involved in cellular migration by activating a proteinase cascade (Wolf et al.,1993).The α-subunit also belongs to the kallikrein gene family (Evans and Richards, 1985). Although α-NGF may protect β-NGF from proteolytic degradation or inhibit NGF biological activity via formation of the 7S complex, a definitive biological function for the α-subunit has not been established." @default.
- W144463400 created "2016-06-24" @default.
- W144463400 creator A5005310008 @default.
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- W144463400 creator A5087777337 @default.
- W144463400 date "1997-01-01" @default.
- W144463400 modified "2023-09-26" @default.
- W144463400 title "Nerve Growth Factor and Oxidative Stress in the Nervous System" @default.
- W144463400 cites W119300755 @default.
- W144463400 cites W12295049 @default.
- W144463400 cites W1486605623 @default.
- W144463400 cites W1497131246 @default.
- W144463400 cites W1505626165 @default.
- W144463400 cites W1507082667 @default.
- W144463400 cites W1525431558 @default.
- W144463400 cites W1528606854 @default.
- W144463400 cites W1531100917 @default.
- W144463400 cites W1538128477 @default.
- W144463400 cites W1545481155 @default.
- W144463400 cites W1548964168 @default.
- W144463400 cites W1566451495 @default.
- W144463400 cites W1568172136 @default.
- W144463400 cites W1568529372 @default.
- W144463400 cites W1572803162 @default.
- W144463400 cites W1582530932 @default.
- W144463400 cites W1582975705 @default.
- W144463400 cites W1593177105 @default.
- W144463400 cites W1600408169 @default.
- W144463400 cites W1605704996 @default.
- W144463400 cites W1609471181 @default.
- W144463400 cites W1664552158 @default.
- W144463400 cites W1673416974 @default.
- W144463400 cites W1745925983 @default.
- W144463400 cites W1777173838 @default.
- W144463400 cites W1830398839 @default.
- W144463400 cites W1857148113 @default.
- W144463400 cites W1891910346 @default.
- W144463400 cites W1898813276 @default.
- W144463400 cites W1910677973 @default.
- W144463400 cites W1945571160 @default.
- W144463400 cites W1966852765 @default.
- W144463400 cites W1967268953 @default.
- W144463400 cites W1969349734 @default.
- W144463400 cites W1969535697 @default.
- W144463400 cites W1970587959 @default.
- W144463400 cites W1972615347 @default.
- W144463400 cites W1972790342 @default.
- W144463400 cites W1973475159 @default.
- W144463400 cites W1975980695 @default.
- W144463400 cites W1977548450 @default.
- W144463400 cites W1978668606 @default.
- W144463400 cites W1979630813 @default.
- W144463400 cites W1980766639 @default.
- W144463400 cites W1983594867 @default.
- W144463400 cites W1984676113 @default.
- W144463400 cites W1984907449 @default.
- W144463400 cites W1985274181 @default.
- W144463400 cites W1985394365 @default.
- W144463400 cites W1985842394 @default.
- W144463400 cites W1985849715 @default.
- W144463400 cites W1988324342 @default.
- W144463400 cites W1989425013 @default.
- W144463400 cites W1992348604 @default.
- W144463400 cites W1993004368 @default.
- W144463400 cites W1994825072 @default.
- W144463400 cites W1996215848 @default.
- W144463400 cites W1996311437 @default.
- W144463400 cites W1996706295 @default.
- W144463400 cites W1996774693 @default.
- W144463400 cites W1997772243 @default.
- W144463400 cites W1998682895 @default.
- W144463400 cites W2000126595 @default.
- W144463400 cites W2000783535 @default.
- W144463400 cites W2003365273 @default.
- W144463400 cites W2006911621 @default.
- W144463400 cites W2006958922 @default.
- W144463400 cites W2008035030 @default.
- W144463400 cites W2014724435 @default.
- W144463400 cites W2019072266 @default.
- W144463400 cites W2019130227 @default.
- W144463400 cites W2020333978 @default.
- W144463400 cites W2020631276 @default.
- W144463400 cites W2021080555 @default.
- W144463400 cites W2025771884 @default.
- W144463400 cites W2027712360 @default.
- W144463400 cites W2030320100 @default.
- W144463400 cites W2030720135 @default.
- W144463400 cites W2031398528 @default.
- W144463400 cites W2041828643 @default.
- W144463400 cites W2041951812 @default.
- W144463400 cites W2048339025 @default.
- W144463400 cites W2050746675 @default.
- W144463400 cites W2051121048 @default.
- W144463400 cites W2052767861 @default.
- W144463400 cites W2054527977 @default.
- W144463400 cites W2055077197 @default.