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• W1444636143 abstract "Most drugs are believed to have concentration-related actions, indicating that receptors show an increasing response with increasing concentration; furthermore, in most instances, the effect of a drug will be maintained if the plasma concentration is maintained. The oral dosage forms, including tablets, capsules, slow-release formulations, exhibit first-order kinetics and share an inability to hold the drug concentration in body tissues constantly. To develop the optimum drug program for such a dosage form, it is necessary to have some understanding of the pharmacokinetic and pharmacodynamic properties of the drug. It is now accepted that by controlling the rate, at which drugs enter the systemic circulation and/or reach their site of action, it is possible to enhance the selectivity of action, by preventing dose-related peaks in blood or tissue drug concentrations that are inevitable with conventional dosage forms. Three rate-specified therapeutic systems have received regulatory approval; two for topical therapy, an ocular and an intrauterine system, and one for systemic therapy, a transdermal system. Thus, innovative dosage form design has made Pilocarpine, prescribed for over 100 years, a much more readily tolerated drug and one that may actually gain in efficacy through more effective administration. The data indicate that therapeutic innovation can be provided without resorting to chemical synthesis of a new drug and usual medication can be effective at lower sustained concentrations." @default.
• W1444636143 created "2016-06-24" @default.
• W1444636143 creator A5014545016 @default.
• W1444636143 date "1980-01-01" @default.
• W1444636143 modified "2023-09-25" @default.
• W1444636143 title "Chapter 31. Drug Delivery Systems" @default.
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• W1444636143 doi "https://doi.org/10.1016/s0065-7743(08)60392-9" @default.
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