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• W1444989744 abstract "Abstract Metabolites have been used as biomarkers for many diseases. The development of highly sensitive and specific metabolite biomarkers may greatly enhance early detection rates, and the identification of potential new targets for therapy. Metabolic dysfunction is a common hallmark of the liver injury-related processes. In order to identify Jaundice syndrome-related biomarkers from urine metabolites, we investigated the specific metabolite profiles of Jaundice syndrome-related animal models by using combined ultraperformance liquid chromatography-mass spectrometry and pattern recognition approaches. This chapter (Parts I and II) introduces the concept of using metabolomics to explore metabolite profiling, and biomarkers analysis; by the establishment of Jaundice syndrome-related rat models induced by d -galactosamine, alcohol, alpha-naphthylisothiocyanate, and carbon tetrachloride. This study could provide insight into global metabolic changes and the mechanisms of pathology in Jaundice syndrome. Jaundice syndrome (JS) rats induced by d -galactosamine (GalN) were used to elucidate the changes in endogenous metabolites and phenotype the metabolic profiling. The rat urine was collected predose (–24to 0 h) and 0–24, 24–48, 48–72, 72–96 h postdose. Mass spectrometry of the urine was analyzed visually and via conjunction with multivariate data analysis, the results demonstrated that there was a time-dependent biochemical effect of GalN dosed on the levels of a range of low-molecular-weight metabolites in urine, which was correlated with the developing phase of JS. Urinary excretion of beta-hydroxybutanoic acid and citric acid were decreased following GalN dosing. Whereas glycocholic acid, indole-3-acetic acid, sphinganine, n-acetyl- l -phenylalanine, cholic acid, and creatinine excretion was increased; which suggests that several key metabolic pathways such as energy metabolism, lipid metabolism, and amino acid metabolism were perturbed by GalN. Alcohol-induced liver disease (ALD) is one of the manifestations of JS, and is a leading cause of nonaccident-related deaths in the world. Identification of an early specific signature for ALD would aid in therapeutic intervention. However, its precise metabolic mechanism has not previously been explored in depth. Urinary metabolomic studies were carried out to identify ALD-associated metabolic biomarkers using rat models that are susceptible to ALD development on chronic alcohol consumption. Ultraperformance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-QTOFMS) combined with pattern recognition approaches were integrated to obtain differentiating metabolites for the pathways and clarify the mechanisms of ALD. Principal components analysis of UPLC-ESI-QTOFMS-generated urinary metabolic fingerprints illustrating that alcohol-treated rats could be distinguished from the control rats. The results indicated that four ions in the positive mode were characterized as potentially differentiating metabolites. These findings demonstrated that mass spectrometry-based metabolomic analysis could help in the identification of ALD-specific signatures. The metabolomics approach may provide insight into the mechanisms of α-naphthylisothiocyanate (ANIT)-induced liver injury. Metabolite profiling was performed by ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-Q-TOF/MS) combined with pathway analysis and pattern recognition approaches including independent component analysis (ICA) and partial least squares-discriminant analysis (PLS-DA). Biochemistry test was also performed for the liver tissue and plasma samples. Five different potential biomarkers in the positive mode contributing to the treatment were discovered. Pathway analysis showed that these metabolites were associated with perturbations in pyrimidine metabolism, primary bile acid biosynthesis, and propanoate metabolism. It showed that changed biomarkers and pathways may provide evidence for insights into disease pathogenesis. Metabolomics technique is the comprehensive assessment of endogenous metabolites in a biological system and may provide additional insight into the mechanisms. Here, the present investigation was designed to explore the possible mechanisms of carbon tetrachloride (CCl4) induced liver injury. Ultraperformance liquid chromatography/electrospray ionization quadruple time-of-flight mass spectrometry (UPLC/ESI-Q-TOF/MS) combined with pattern recognition approaches including principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were integrated to discover differentiating metabolites of liver injury rats induced by carbon tetrachloride (CCl4). Five ions were found in the positive mode as differentiating metabolites. Of note, functional pathway analysis revealed that the alterations in these metabolites were associated with primary bile acid biosynthesis and pyrimidine metabolism." @default.
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• W1444989744 date "2015-01-01" @default.
• W1444989744 modified "2023-09-25" @default.
• W1444989744 title "Metabolite Profiling and Biomarkers Analysis of Jaundice Syndrome-Related Animal Models" @default.
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• W1444989744 doi "https://doi.org/10.1016/b978-0-12-803117-9.00008-1" @default.
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