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- W1445815237 abstract "This chapter describes in detail the role of bis-(3',5')-cyclic di-GMP (c-di-GMP) signaling in the expression of the rdar morphotype, one of the major targets of c-di-GMP signaling in Salmonella enterica serovar Typhimurium. It describes the impact of this multicellular morphotype and the complex molecular mechanisms by which it is regulated. Further, the chapter discusses the role of c-di-GMP in motility and characterizes the upcoming molecular mechanisms that tightly control the switch between the sedentary state and motility at various levels in the respective regulatory cascades. Initial characterization of the growth of S. enterica serovar Typhimurium in rdar morphotype colonies on agar plates demonstrated that the formation of this morphotype represents a specific form of multicellular behavior (biofilm) in bacteria. An intrinsic characteristic of biofilm formation, the formation of a self-produced extracellular matrix, is required to construct the complex three dimensional architecture of the biofilm. Expression of the rdar morphotype is usually highly controlled in response to environmental conditions. With few exceptions, under laboratory conditions, the rdar morphotype is expressed on Luria broth agar plates without salt at temperatures below 30№C. Experiments in which adrA, encoding a highly potent diguanylate cyclase (DGC), and STM3611, encoding a highly potent phosphodiesterase (PDE), were overexpressed first indicated c-di-GMP-dependent regulation of CsgD expression." @default.
- W1445815237 created "2016-06-24" @default.
- W1445815237 creator A5000556766 @default.
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- W1445815237 creator A5081974103 @default.
- W1445815237 creator A5091248343 @default.
- W1445815237 date "2014-04-30" @default.
- W1445815237 modified "2023-10-03" @default.
- W1445815237 title "Hierarchical Control of rdar Morphotype Development of Salmonella enterica by Cyclic Di-GMP" @default.
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