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• W1445829435 abstract "BackgroundGenetic variations in dystrobrevin binding protein 1 (DTNBP1 or dysbindin-1) have been implicated as risk factors in the pathogenesis of schizophrenia. The encoded protein dysbindin-1 functions in the regulation of synaptic activity and synapse development. Intriguingly, a loss of function mutation in Dtnbp1 in mice disrupted both glutamatergic and gamma-aminobutyric acidergic transmission in the cerebral cortex; pyramidal neurons displayed enhanced excitability due to reductions in inhibitory synaptic inputs. However, the mechanism by which reduced dysbindin-1 activity causes inhibitory synaptic deficits remains unknown.MethodsWe investigated the role of dysbindin-1 in the exocytosis of brain-derived neurotrophic factor (BDNF) from cortical excitatory neurons, organotypic brain slices, and acute slices from dysbindin-1 mutant mice and determined how this change in BDNF exocytosis transsynaptically affected the number of inhibitory synapses formed on excitatory neurons via whole-cell recordings, immunohistochemistry, and live-cell imaging using total internal reflection fluorescence microscopy.ResultsA decrease in dysbindin-1 reduces the exocytosis of BDNF from cortical excitatory neurons, and this reduction in BDNF exocytosis transsynaptically resulted in reduced inhibitory synapse numbers formed on excitatory neurons. Furthermore, application of exogenous BDNF rescued the inhibitory synaptic deficits caused by the reduced dysbindin-1 level in both cultured cortical neurons and slice cultures.ConclusionsTaken together, our results demonstrate that these two genes linked to risk for schizophrenia (BDNF and dysbindin-1) function together to regulate interneuron development and cortical network activity. This evidence supports the investigation of the association between dysbindin-1 and BDNF in humans with schizophrenia." @default.
• W1445829435 created "2016-06-24" @default.
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• W1445829435 date "2016-08-01" @default.
• W1445829435 modified "2023-10-14" @default.
• W1445829435 title "Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1" @default.
• W1445829435 cites W1489463875 @default.
• W1445829435 cites W1512252703 @default.
• W1445829435 cites W1751920974 @default.
• W1445829435 cites W1970235440 @default.
• W1445829435 cites W1971455831 @default.
• W1445829435 cites W1975599306 @default.
• W1445829435 cites W1982810155 @default.
• W1445829435 cites W1983046843 @default.
• W1445829435 cites W1984070984 @default.
• W1445829435 cites W1988013008 @default.
• W1445829435 cites W1991545156 @default.
• W1445829435 cites W1994360115 @default.
• W1445829435 cites W1998341727 @default.
• W1445829435 cites W2000540402 @default.
• W1445829435 cites W2000637724 @default.
• W1445829435 cites W2001532503 @default.
• W1445829435 cites W2001555806 @default.
• W1445829435 cites W2007816528 @default.
• W1445829435 cites W2008934254 @default.
• W1445829435 cites W2011953956 @default.
• W1445829435 cites W2011961744 @default.
• W1445829435 cites W2015921109 @default.
• W1445829435 cites W2016166286 @default.
• W1445829435 cites W2016854825 @default.
• W1445829435 cites W2020914828 @default.
• W1445829435 cites W2026037056 @default.
• W1445829435 cites W2026590190 @default.
• W1445829435 cites W2029037348 @default.
• W1445829435 cites W2030926288 @default.
• W1445829435 cites W2031240433 @default.
• W1445829435 cites W2031534534 @default.
• W1445829435 cites W2032499353 @default.
• W1445829435 cites W2042325100 @default.
• W1445829435 cites W2043321552 @default.
• W1445829435 cites W2046033738 @default.
• W1445829435 cites W2049942785 @default.
• W1445829435 cites W2058428720 @default.
• W1445829435 cites W2065171944 @default.
• W1445829435 cites W2069383451 @default.
• W1445829435 cites W2073239561 @default.
• W1445829435 cites W2074795674 @default.
• W1445829435 cites W2076079955 @default.
• W1445829435 cites W2076347107 @default.
• W1445829435 cites W2077584114 @default.
• W1445829435 cites W2081406198 @default.
• W1445829435 cites W2083140052 @default.
• W1445829435 cites W2084793241 @default.
• W1445829435 cites W2086069938 @default.
• W1445829435 cites W2086675603 @default.
• W1445829435 cites W2089912569 @default.
• W1445829435 cites W2093411259 @default.
• W1445829435 cites W2097364564 @default.
• W1445829435 cites W2101200615 @default.
• W1445829435 cites W2102004133 @default.
• W1445829435 cites W2105527159 @default.
• W1445829435 cites W2106319065 @default.
• W1445829435 cites W2106758010 @default.
• W1445829435 cites W2108696245 @default.
• W1445829435 cites W2110696099 @default.
• W1445829435 cites W2117959142 @default.
• W1445829435 cites W2125978816 @default.
• W1445829435 cites W2131993013 @default.
• W1445829435 cites W2142746886 @default.
• W1445829435 cites W2145936065 @default.
• W1445829435 cites W2149858533 @default.
• W1445829435 cites W2165643659 @default.
• W1445829435 cites W4252627448 @default.
• W1445829435 doi "https://doi.org/10.1016/j.biopsych.2015.08.019" @default.
• W1445829435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26386481" @default.
• W1445829435 hasPublicationYear "2016" @default.
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