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- W144583527 abstract "The relationship between red meat consumption and colorectal cancer (CRC) has been the subject of scientific debate. Thus, to estimate the summary association between red meat intake and CRC and to examine heterogeneity, a meta-analysis of prospective studies was conducted. Thirty-four prospective studies of red meat and CRC were identified, of which, 24 represented independent non-overlapping study populations. Random effects meta-analysis models were utilized to calculate summary relative risk estimates (SRREs) for high vs. low intake and dose-response relationships. In the high vs. low intake meta-analysis of all studies, the SRRE was 1.13 (95% CI: 1.04–1.23), although there was significant heterogeneity (p = 0.016). Summary associations were modified by tumor site and gender. The SRREs for colon cancer and rectal cancer were 1.11 (95% CI: 1.03–1.19) and 1.19 (95% CI: 0.97–1.46), respectively. The SRREs among men and women were 1.21 (95% CI: 1.04–1.42) and 1.01 (95% CI: 0.87–1.17), respectively. The available epidemiologic data are not sufficient to support an independent positive association between red meat intake and CRC. This conclusion is based upon summary associations that are weak in magnitude, heterogeneity between available studies, inconsistent patterns of associations across the sub-groups analyses, and the likely influence of confounding by other dietary and lifestyle factors." @default.
- W144583527 created "2016-06-24" @default.
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- W144583527 date "2010-04-01" @default.
- W144583527 modified "2023-09-26" @default.
- W144583527 title "Meta‐Analysis of Prospective Studies of Red Meat Consumption and Colorectal Cancer" @default.
- W144583527 doi "https://doi.org/10.1096/fasebj.24.1_supplement.207.5" @default.
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