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• W14463810 endingPage "1631" @default.
• W14463810 startingPage "1625" @default.
• W14463810 abstract "Abusive head trauma (AHT) is a unique form of pediatric TBI with increased mortality and neurologic sequelae. Hemispheric hypodensity (HH) in association with subdural blood after AHT has been described. Though risk factors for HH are not understood, we hypothesized that risk factors could be identified. We retrospectively enrolled children under 5 years with TBI secondary to AHT (child advocacy diagnosis) who had undergone initial and interval brain imaging. Records were interrogated for prearrival and in-hospital physiologic and radiographic findings. HH was determined by a blinded observer. Twenty-four children were enrolled and 13 developed HH. HH was not significantly associated with age, initial Glascow Coma Scale, or mortality. Pediatric Intensity Level of Therapy (PILOT) scores (p=0.01) and daily maximal intracranial pressure (ICPmax; p=0.037) were higher in HH. Hypoxia, hypotension, cardiopulmonary arrest, need for blood transfusion, and daily blood glucoses tended to be greater in HH. Whereas all children with HH had acute subdural hematoma (SBH), many children without HH also had subdural blood; the presence of skull fracture was more likely in the children who did not develop HH (p=0.04), but no other intracranial radiographic pattern of injury was associated with HH. Surgical intervention did not appear to protect against development of HH. A variety of insults associated with ischemia, including intracranial hypertension, ICP-directed therapies, hypoxia, hypotension, and cardiac arrest, occurred in the children who developed HH. Given the morbidity and mortality of this condition, larger studies to identify mechanisms leading to the development of HH and mitigating clinical approaches are warranted." @default.
• W14463810 created "2016-06-24" @default.
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• W14463810 creator A5051917481 @default.
• W14463810 creator A5069349073 @default.
• W14463810 creator A5086247364 @default.
• W14463810 date "2014-10-01" @default.
• W14463810 modified "2023-10-06" @default.
• W14463810 title "Factors Associated with Hemispheric Hypodensity after Subdural Hematoma following Abusive Head Trauma in Children" @default.
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• W14463810 doi "https://doi.org/10.1089/neu.2014.3372" @default.
• W14463810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4171388" @default.
• W14463810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24693985" @default.
• W14463810 hasPublicationYear "2014" @default.
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