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- W1446391111 abstract "Studies in this laboratory have suggested that mature collagen might be reutilized (Klein et al,, 1962, 1964; Klein, 1964). The induction of granulation tissue in animals previously labeled with radioactive proline would determine whether mature fibrous collagen is reutilized in the formation of new connective tissue, because only the pre-existing collagen would be radioactive. MATERIALS AND METHODS Animals. Young female guinea pigs weighing 220-250 g, young female Fischer rats weighing 56-74 g, and young female SpragueDawley rats weighing 84-94 g were used. The animals were placed on Purina guinea pig and rat chow ad libitum. Labeling procedure. Uniformly labeled L-proline-Cl4 was obtained from Schwarz Bioresearch (175 mC/mM), and L-proline-3,4-H3 from New England Nuclear Corp. (5 c/mM). During the active growing phase, each animal was given an intraperitoneal injection of radioactive proline (0.25 microcurie/g), twice per week for 4 weeks, The guinea pigs received a total of 350-600 microcuries" @default.
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- W1446391111 date "1965-11-01" @default.
- W1446391111 modified "2023-09-27" @default.
- W1446391111 title "Reutilization of mature collagen in, vivo" @default.
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- W1446391111 doi "https://doi.org/10.1016/0006-291x(65)90194-4" @default.
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