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- W1446404209 abstract "Cis-dichlorodiammineplatinum has been shown to be highly success? ful in arresting cell division, however, clinical Phase XI trials have shown a development of tubular necrosis after repeated doses. Therefore, an investigation of the effects of this agent on isolated tubules, and in? tact perfused kidneys of the rabbit were performed, A cellular hypertrophy with vacuolization preceded the loss of the luminal brush border in the proximal tubule. The results indicated a cytotoxic effect from platinum, rather than a specific enzymatic inhibition. Membrane transport and me? tabolism of the isolated proximal tubules paralleled the effects of the in situ perfused kidney while under the influence of cls?DPP, The kid? ney's ability to concentrate cis-DDP supported the findings that continuous exposure of the drug led to the elevated levels of platinum that could be responsible for the change in morphology and cell function seen in this" @default.
- W1446404209 created "2016-06-24" @default.
- W1446404209 creator A5083334438 @default.
- W1446404209 date "1979-01-01" @default.
- W1446404209 modified "2023-09-24" @default.
- W1446404209 title "THE EFFECTS OF CIS-PLATINUM ON THE ISOLATED PERFUSED RABBIT KIDNEY AND ISOLATED KIDNEY TUBULES" @default.
- W1446404209 hasPublicationYear "1979" @default.
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