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- W1446662016 abstract "This chapter discusses the potential roles of oxygen free radicals and cholesterol in the pathogenesis of Alzheimer's disease (AD). Results from the laboratory suggest that the cholesterol content in plasma and brain of Alzheimer's-transgenic mice is strongly correlated with the rate of development of amyloid pathology. The data suggest two potential mechanisms whereby hypercholesterolemia accelerates brain β-amyloid accumulation. Most recent developments in the study of AD pathogenesis resulted from the compositional analysis of senile plaques and neurofibrillary tangles that began over two decades ago. These research efforts have provided intriguing information about the role of several factors, including cholesterol and oxidative stress, in the pathogenesis of this condition. Although many facets of the biology and genetics of this disease remain to be discovered, strides have been made toward developing animal models and elucidating the biological properties of several proteins, such as AB, APP, presenilins, and apolipoproteins, and of factors that can modulate their interactions. This information has resulted in the development of strategies aimed at either reducing production or aggregation of Aβ or at blocking the neurotoxicity and inflammation that this peptide appears to cause in brain regions responsible for intellectual functioning." @default.
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- W1446662016 date "2003-01-01" @default.
- W1446662016 modified "2023-10-14" @default.
- W1446662016 title "Cholesterol, β-amyloid, and Alzheimer's disease" @default.
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- W1446662016 doi "https://doi.org/10.1016/s1566-3124(03)12009-3" @default.
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