FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W144667968> ?p ?o ?g. }

• W144667968 endingPage "258" @default.
• W144667968 startingPage "241" @default.
• W144667968 abstract "Antiphospholipid antibodies are strongly associated with thrombosis and are the most common of the acquired blood protein defects causing thrombosis. Although the precise mechanism(s) whereby antiphospholipid antibodies alter hemostasis to induce a hypercoagutable state remain unclear, numerous theories, as previously discussed, have been advanced. The most common thrombotic events associated with anticardiolipin antibodies are deep vein thrombosis and pulmonary embolus (type I syndrome), coronary or peripheral artery thrombosis (type II syndrome), or cerebrovascular/retinal vessel thrombosis (type II syndrome); occasionally, patients present with mixtures of these types (type IV syndrome). Type V patients are those with antiphospholipid antibodies and RMS. It is as yet unclear how many seemingly normal individuals who may never develop manifestations of antiphospholipid syndrome (type VI) harbor asymptomatic antiphospholipid antibodies. The relative frequency of anticardiolipin antibodies in association with arterial and venous thrombosis strongly suggests that these should be looked for in any individual with unexplained thrombosis; all three idiotypes (IgG, IgA, and IgM) should be assessed. Also, the type of syndrome (I through VI) should be defined if possible, as this may dictate both type and duration of both immediate and long-term anticoagulant therapy. Unlike those with anticardiolipin antibodies, patients with primary lupus anticoagulant thrombosis syndrome usually experience venous thrombosis. Because the aPTT is unreliable inpatients with lupus anticoagulant (prolonged in only about 40 to 50% of patients) and is not usually prolonged in patients with anticardiolipin antibodies, definitive tests, including ELISA for anticardiolipin antibodies, the dRVVT for lupus anticoagulant, hexagonal phospholipid neutralization procedure, and beta-2-GP-I (IgG, IgA, and IgM) should be immediately ordered when suspecting antiphospholipid syndrome or in individuals with otherwise unexplained thrombotic or thromboembolic events. If results of these tests are negative, in the appropriate clinical setting, subgroups should also be assessed. Finally, most patients with antiphospholipid thrombosis syndrome will fail warfarin therapy and, except for retinal vascular thrombosis, may fail some types of antiplatelet therapy; thus it is of major importance to make this diagnosis so that patients can be treated with the most effective therapy for secondary prevention--LMWH or UH in most instances, and clopidogrel in some instances." @default.
• W144667968 created "2016-06-24" @default.
• W144667968 creator A5007201914 @default.
• W144667968 date "2001-10-01" @default.
• W144667968 modified "2023-09-23" @default.
• W144667968 title "State-of-the-Art Review: Antiphospholipid Thrombosis Syndromes" @default.
• W144667968 cites W104075595 @default.
• W144667968 cites W113327545 @default.
• W144667968 cites W134017157 @default.
• W144667968 cites W1491481195 @default.
• W144667968 cites W150620516 @default.
• W144667968 cites W1522420709 @default.
• W144667968 cites W1546252777 @default.
• W144667968 cites W1549226126 @default.
• W144667968 cites W1596313173 @default.
• W144667968 cites W1964831532 @default.
• W144667968 cites W1965330054 @default.
• W144667968 cites W1965428387 @default.
• W144667968 cites W1966789636 @default.
• W144667968 cites W1966862034 @default.
• W144667968 cites W1967602919 @default.
• W144667968 cites W1973804186 @default.
• W144667968 cites W1975338420 @default.
• W144667968 cites W1975968032 @default.
• W144667968 cites W1976003645 @default.
• W144667968 cites W1976131481 @default.
• W144667968 cites W1976822483 @default.
• W144667968 cites W1979178692 @default.
• W144667968 cites W1980784832 @default.
• W144667968 cites W1982022347 @default.
• W144667968 cites W1983431134 @default.
• W144667968 cites W1986005339 @default.
• W144667968 cites W1987373773 @default.
• W144667968 cites W1993393605 @default.
• W144667968 cites W1998182120 @default.
• W144667968 cites W1998804246 @default.
• W144667968 cites W2000055469 @default.
• W144667968 cites W2002197774 @default.
• W144667968 cites W2002418841 @default.
• W144667968 cites W2003399830 @default.
• W144667968 cites W2005073274 @default.
• W144667968 cites W2007942329 @default.
• W144667968 cites W2011577434 @default.
• W144667968 cites W2017152754 @default.
• W144667968 cites W2018351960 @default.
• W144667968 cites W2021180116 @default.
• W144667968 cites W2022782223 @default.
• W144667968 cites W2026056441 @default.
• W144667968 cites W2026105288 @default.
• W144667968 cites W2026836398 @default.
• W144667968 cites W2027179530 @default.
• W144667968 cites W2029808693 @default.
• W144667968 cites W2030238244 @default.
• W144667968 cites W2032084961 @default.
• W144667968 cites W2032377209 @default.
• W144667968 cites W2032512462 @default.
• W144667968 cites W2032831604 @default.
• W144667968 cites W2040236551 @default.
• W144667968 cites W2040237069 @default.
• W144667968 cites W204108417 @default.
• W144667968 cites W2045376284 @default.
• W144667968 cites W2046421493 @default.
• W144667968 cites W2046771483 @default.
• W144667968 cites W2048927559 @default.
• W144667968 cites W2049127704 @default.
• W144667968 cites W2060671359 @default.
• W144667968 cites W2061580340 @default.
• W144667968 cites W2061976798 @default.
• W144667968 cites W2064843116 @default.
• W144667968 cites W2065238301 @default.
• W144667968 cites W2065380428 @default.
• W144667968 cites W2066929104 @default.
• W144667968 cites W2071407184 @default.
• W144667968 cites W2071761809 @default.
• W144667968 cites W2072349587 @default.
• W144667968 cites W2074960786 @default.
• W144667968 cites W2079963792 @default.
• W144667968 cites W2080582867 @default.
• W144667968 cites W2081171256 @default.
• W144667968 cites W2081857175 @default.
• W144667968 cites W2084026328 @default.
• W144667968 cites W2084997251 @default.
• W144667968 cites W2089978472 @default.
• W144667968 cites W2094462645 @default.
• W144667968 cites W2100370890 @default.
• W144667968 cites W2103720854 @default.
• W144667968 cites W2108044881 @default.
• W144667968 cites W2108845205 @default.
• W144667968 cites W2109554221 @default.
• W144667968 cites W2110686378 @default.
• W144667968 cites W2113698539 @default.
• W144667968 cites W2115528623 @default.
• W144667968 cites W2120562157 @default.
• W144667968 cites W2120586298 @default.
• W144667968 cites W2122553993 @default.
• W144667968 cites W2126767646 @default.
• W144667968 cites W2127278284 @default.
• W144667968 cites W2138858884 @default.

• next