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- W1447972144 abstract "To investigate the possible relationship and mechanism of Toll-like receptor 4 (TLR4) and acute lung injury induced by paraquat (PQ) poisoning.Male wild type mice and male TLR4-knockout mice were used in this study. After paraquat treatment for 24 hours, mice were euthanized and pathology, TLR4 expression and pro-inflammatory cytokines were evaluated.Wild type mice showed deteriorated lung injury, pathological damages and increased TLR4 expression and pulmonary TNF-α, IL-1β and NF-κB p65 levels after PQ treatment. TLR4-deficient mice were significantly resistant to paraquat-induced lung injury.TLR4 may be required as a mediator and may play an important role in acute lung injury induced by paraquat." @default.
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- W1447972144 date "2014-01-01" @default.
- W1447972144 modified "2023-09-23" @default.
- W1447972144 title "Toll-like receptor 4 implicated in acute lung injury induced by paraquat poisoning in mice." @default.
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