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• W1448319635 abstract "This chapter discusses the cerebellar granule cells in normal and neurological mutants of mice. The cerebellum is probably the most comprehensively studied area of the brain. The cerebellar cortex is characterized by a trilaminar—granule, Purkinje, and molecular—structure and contains only five different neuronal cell classes, namely, granule, Purkinje, basket, stellate, and Golgi, that interconnect in a rigid geometry of repeating groups presumed to be responsible for specific information processing. The development of this highly organized area of the brain has received a great deal of attention, partly because of its well-defined physiology, cell types, and architecture, and partly because of the availability of mouse mutations that perturb the normal sequence of development, allowing analysis of individual events. The chapter presents two neurological mutants, namely, staggerer (sg/sg) and weaver (wv/wv), in which granule cells degenerate almost completely. It focuses on the approaches that lead to information on what is transpiring at the cellular level in the mutant cerebella and, by inference, on what may be happening in the normal case. In addition to the microscopic structure of brains perfused in vivo, the chapter also highlights studies that use newer techniques for dissection of cellular processes." @default.
• W1448319635 created "2016-06-24" @default.
• W1448319635 creator A5019220405 @default.
• W1448319635 date "1980-01-01" @default.
• W1448319635 modified "2023-10-16" @default.
• W1448319635 title "Cerebellar Granule Cells in Normal and Neurological Mutants of Mice" @default.
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• W1448319635 doi "https://doi.org/10.1016/b978-0-12-008301-5.50009-1" @default.
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