FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1448496733> ?p ?o ?g. }

• W1448496733 abstract "Auto-regulation, a process wherein a protein negatively regulates its own production, is a common motif in gene expression networks. Negative feedback in gene expression plays a critical role in buffering intracellular fluctuations in protein concentrations around optimal value. Due to the nonlinearities present in these feedbacks, moment dynamics are typically not closed, in the sense that the time derivative of the lower-order statistical moments of the protein copy number depends on high-order moments. Moment equations are closed by expressing higher-order moments as nonlinear functions of lower-order moments, a technique commonly referred to as moment closure. Here, we compare the performance of different moment closure techniques. Our results show that the commonly used closure method, which assumes a priori that the protein population counts are normally distributed, performs poorly. In contrast, conditional derivative matching, a novel closure scheme proposed here provides a good approximation to the exact moments across different parameter regimes. In summary our study provides a new moment closure method for studying stochastic dynamics of genetic negative feedback circuits, and can be extended to probe noise in more complex gene networks." @default.
• W1448496733 created "2016-06-24" @default.
• W1448496733 creator A5004129233 @default.
• W1448496733 creator A5022267407 @default.
• W1448496733 creator A5034221719 @default.
• W1448496733 creator A5048266570 @default.
• W1448496733 creator A5074452669 @default.
• W1448496733 date "2014-05-15" @default.
• W1448496733 modified "2023-10-12" @default.
• W1448496733 title "Moment Closure Approximations in a Genetic Negative Feedback Circuit" @default.
• W1448496733 cites W1599969036 @default.
• W1448496733 cites W1946177469 @default.
• W1448496733 cites W1964261044 @default.
• W1448496733 cites W1967146963 @default.
• W1448496733 cites W1970970926 @default.
• W1448496733 cites W1973960290 @default.
• W1448496733 cites W1974272479 @default.
• W1448496733 cites W1978750558 @default.
• W1448496733 cites W1984916226 @default.
• W1448496733 cites W2001053085 @default.
• W1448496733 cites W2028960254 @default.
• W1448496733 cites W2037768790 @default.
• W1448496733 cites W2044692345 @default.
• W1448496733 cites W2047515584 @default.
• W1448496733 cites W2053460598 @default.
• W1448496733 cites W2054908452 @default.
• W1448496733 cites W2059053384 @default.
• W1448496733 cites W2061425021 @default.
• W1448496733 cites W2073094004 @default.
• W1448496733 cites W2076367743 @default.
• W1448496733 cites W2077046573 @default.
• W1448496733 cites W2078119846 @default.
• W1448496733 cites W2084924279 @default.
• W1448496733 cites W2096705138 @default.
• W1448496733 cites W2102869475 @default.
• W1448496733 cites W2117144170 @default.
• W1448496733 cites W2151364744 @default.
• W1448496733 cites W2155202381 @default.
• W1448496733 cites W2161406501 @default.
• W1448496733 cites W2166447119 @default.
• W1448496733 cites W2167244112 @default.
• W1448496733 cites W2170704198 @default.
• W1448496733 cites W2171280873 @default.
• W1448496733 cites W2171769276 @default.
• W1448496733 hasPublicationYear "2014" @default.
• W1448496733 type Work @default.
• W1448496733 sameAs 1448496733 @default.
• W1448496733 citedByCount "2" @default.
• W1448496733 countsByYear W14484967332015 @default.
• W1448496733 countsByYear W14484967332017 @default.
• W1448496733 crossrefType "posted-content" @default.
• W1448496733 hasAuthorship W1448496733A5004129233 @default.
• W1448496733 hasAuthorship W1448496733A5022267407 @default.
• W1448496733 hasAuthorship W1448496733A5034221719 @default.
• W1448496733 hasAuthorship W1448496733A5048266570 @default.
• W1448496733 hasAuthorship W1448496733A5074452669 @default.
• W1448496733 hasConcept C105795698 @default.
• W1448496733 hasConcept C111472728 @default.
• W1448496733 hasConcept C121332964 @default.
• W1448496733 hasConcept C121864883 @default.
• W1448496733 hasConcept C134306372 @default.
• W1448496733 hasConcept C138885662 @default.
• W1448496733 hasConcept C144024400 @default.
• W1448496733 hasConcept C146834321 @default.
• W1448496733 hasConcept C149923435 @default.
• W1448496733 hasConcept C154945302 @default.
• W1448496733 hasConcept C158622935 @default.
• W1448496733 hasConcept C162324750 @default.
• W1448496733 hasConcept C165064840 @default.
• W1448496733 hasConcept C17685861 @default.
• W1448496733 hasConcept C179254644 @default.
• W1448496733 hasConcept C196558001 @default.
• W1448496733 hasConcept C2775924081 @default.
• W1448496733 hasConcept C2778513689 @default.
• W1448496733 hasConcept C28826006 @default.
• W1448496733 hasConcept C2908647359 @default.
• W1448496733 hasConcept C33923547 @default.
• W1448496733 hasConcept C34447519 @default.
• W1448496733 hasConcept C41008148 @default.
• W1448496733 hasConcept C47446073 @default.
• W1448496733 hasConcept C57879066 @default.
• W1448496733 hasConcept C62520636 @default.
• W1448496733 hasConcept C74650414 @default.
• W1448496733 hasConcept C75553542 @default.
• W1448496733 hasConceptScore W1448496733C105795698 @default.
• W1448496733 hasConceptScore W1448496733C111472728 @default.
• W1448496733 hasConceptScore W1448496733C121332964 @default.
• W1448496733 hasConceptScore W1448496733C121864883 @default.
• W1448496733 hasConceptScore W1448496733C134306372 @default.
• W1448496733 hasConceptScore W1448496733C138885662 @default.
• W1448496733 hasConceptScore W1448496733C144024400 @default.
• W1448496733 hasConceptScore W1448496733C146834321 @default.
• W1448496733 hasConceptScore W1448496733C149923435 @default.
• W1448496733 hasConceptScore W1448496733C154945302 @default.
• W1448496733 hasConceptScore W1448496733C158622935 @default.
• W1448496733 hasConceptScore W1448496733C162324750 @default.
• W1448496733 hasConceptScore W1448496733C165064840 @default.
• W1448496733 hasConceptScore W1448496733C17685861 @default.
• W1448496733 hasConceptScore W1448496733C179254644 @default.
• W1448496733 hasConceptScore W1448496733C196558001 @default.

• next