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- W1448893191 abstract "Ciliary neurotrophic factor (CNTF) is a promyelinatingtrophic factor that protects cells from demyelination. Mechanisms by which CNTF level could be enriched in the CNS are poorly understood. This study underlines the importance of cinnamon metabolite sodium benzoate (NaB) in increasing the level of CNTF in astrocytes and oligodendrocytes. NaB alone upregulated the expression of CNTF in primary mouse astrocytes and oligodendrocytes. Accordingly, oral administration of NaB and cinnamon increased the levels of CNTF in astrocytes and oligodendrocytes in vivo in the CNS of mice. While investigating mechanisms, we found that NaB induced the activation of protein kinase A (PKA) and that H-89, an inhibitor of PKA, hindered NaB-induced expression of CNTF. Moreover, NaB treatment increased the phosphorylation of cAMP response element-binding protein (CREB) and CREB siRNA abrogated NaB-induced expression of CNTF. Furthermore, the Cntf promoter harbors one consensus cAMP-response element and NaB treatment induces the recruitment of CREB to the Cntf promoter. These results highlight a novel role of NaB in myelination in which NaB upregulates CNTF via PKA-CREB pathway." @default.
- W1448893191 created "2016-06-24" @default.
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- W1448893191 date "2015-04-01" @default.
- W1448893191 modified "2023-09-27" @default.
- W1448893191 title "Upregulation of Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes by Cinnamon Metabolite Sodium Benzoate: Implications for Demyelinating Disorders" @default.
- W1448893191 doi "https://doi.org/10.1096/fasebj.29.1_supplement.728.27" @default.
- W1448893191 hasPublicationYear "2015" @default.
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