Matches in SemOpenAlex for { <https://semopenalex.org/work/W14495360> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W14495360 endingPage "53" @default.
- W14495360 startingPage "244" @default.
- W14495360 abstract "Advances in the understanding of the pathogenesis of psoriasis have led to the development of biologic agents that target T cells and cytokines that play a specific role in the underlying inflammation associated with psoriasis (eg, tumor necrosis factor-α inhibitors, interleukin [IL]-12/23 inhibitors). In this review, evidence for the central role of IL-17 in the pathophysiology of psoriasis is presented, along with available clinical trial data on the selective IL-17 inhibitors in development. Three biologic agents that target IL-17 are currently in clinical development: secukinumab, ixekizumab, and brodalumab. Clinical studies to date suggest a favorable safety profile and the potential for better efficacy over the previous generation of agents, with Psoriasis Area Severity Index 75 response rates of up to 80% or greater. Fully published results of phase III studies of these agents are eagerly awaited." @default.
- W14495360 created "2016-06-24" @default.
- W14495360 creator A5012715289 @default.
- W14495360 creator A5052851982 @default.
- W14495360 date "2015-03-01" @default.
- W14495360 modified "2023-09-23" @default.
- W14495360 title "Next-generation biologics in the management of plaque psoriasis: a literature review of IL-17 inhibition." @default.
- W14495360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25738846" @default.
- W14495360 hasPublicationYear "2015" @default.
- W14495360 type Work @default.
- W14495360 sameAs 14495360 @default.
- W14495360 citedByCount "5" @default.
- W14495360 countsByYear W144953602016 @default.
- W14495360 countsByYear W144953602017 @default.
- W14495360 countsByYear W144953602018 @default.
- W14495360 countsByYear W144953602019 @default.
- W14495360 crossrefType "journal-article" @default.
- W14495360 hasAuthorship W14495360A5012715289 @default.
- W14495360 hasAuthorship W14495360A5052851982 @default.
- W14495360 hasConcept C126322002 @default.
- W14495360 hasConcept C16005928 @default.
- W14495360 hasConcept C17991360 @default.
- W14495360 hasConcept C203014093 @default.
- W14495360 hasConcept C2776260265 @default.
- W14495360 hasConcept C2777011040 @default.
- W14495360 hasConcept C2777575956 @default.
- W14495360 hasConcept C2778690821 @default.
- W14495360 hasConcept C2778975655 @default.
- W14495360 hasConcept C2779745271 @default.
- W14495360 hasConcept C2779786854 @default.
- W14495360 hasConcept C2780132546 @default.
- W14495360 hasConcept C2780564577 @default.
- W14495360 hasConcept C2911221801 @default.
- W14495360 hasConcept C3020604521 @default.
- W14495360 hasConcept C535046627 @default.
- W14495360 hasConcept C71924100 @default.
- W14495360 hasConcept C74172505 @default.
- W14495360 hasConceptScore W14495360C126322002 @default.
- W14495360 hasConceptScore W14495360C16005928 @default.
- W14495360 hasConceptScore W14495360C17991360 @default.
- W14495360 hasConceptScore W14495360C203014093 @default.
- W14495360 hasConceptScore W14495360C2776260265 @default.
- W14495360 hasConceptScore W14495360C2777011040 @default.
- W14495360 hasConceptScore W14495360C2777575956 @default.
- W14495360 hasConceptScore W14495360C2778690821 @default.
- W14495360 hasConceptScore W14495360C2778975655 @default.
- W14495360 hasConceptScore W14495360C2779745271 @default.
- W14495360 hasConceptScore W14495360C2779786854 @default.
- W14495360 hasConceptScore W14495360C2780132546 @default.
- W14495360 hasConceptScore W14495360C2780564577 @default.
- W14495360 hasConceptScore W14495360C2911221801 @default.
- W14495360 hasConceptScore W14495360C3020604521 @default.
- W14495360 hasConceptScore W14495360C535046627 @default.
- W14495360 hasConceptScore W14495360C71924100 @default.
- W14495360 hasConceptScore W14495360C74172505 @default.
- W14495360 hasIssue "3" @default.
- W14495360 hasLocation W144953601 @default.
- W14495360 hasOpenAccess W14495360 @default.
- W14495360 hasPrimaryLocation W144953601 @default.
- W14495360 hasRelatedWork W14495360 @default.
- W14495360 hasRelatedWork W2203736446 @default.
- W14495360 hasRelatedWork W2701201582 @default.
- W14495360 hasRelatedWork W2769068226 @default.
- W14495360 hasRelatedWork W2984358265 @default.
- W14495360 hasRelatedWork W3183768684 @default.
- W14495360 hasRelatedWork W4212859985 @default.
- W14495360 hasRelatedWork W4213351251 @default.
- W14495360 hasRelatedWork W4248008924 @default.
- W14495360 hasRelatedWork W864584325 @default.
- W14495360 hasVolume "14" @default.
- W14495360 isParatext "false" @default.
- W14495360 isRetracted "false" @default.
- W14495360 magId "14495360" @default.
- W14495360 workType "article" @default.