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- W1451465362 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064514 Background: Endometrial cancer is the most common gynecologic malignancy of western women. The disease generally has a favourable prognosis with a 75% 5-year survival. There is still a need for reliable tumor markers for identification of high-risk patients. This would provide an improved basis for individualized treatment and potentially reduce morbidity in low-risk groups. Aim: The aim of this study was to identify signatures of differentially expressed genes in aggressive endometrial carcinomas. Materials and Methods: Carefully dissected fresh endometrial cancer tissues were prospectively collected from 57 patients treated for primary endometrial cancer. Microarray analysis was performed using Agilent DNA oligonucleotide microarrays (21K). Tissue microarrays from a separate population based validation series of 316 endometrial carcinomas with long and complete follow-up were included. Results: Unsupervised analysis revealed 2 distinct patient clusters being significantly associated with FIGO stage, histologic type and grade (p=0.001), presence of vessel infiltration, necrosis, number of mitoses and prognosis (recurrence free survival, log-rank test, p=0.03). We are in the process of validating differentially expressed genes by using low-density arrays and a separate patient series with follow-up information. Conclusions: Gene expression data provided tumor clusters which were significantly associated with clinico-pathologic features and patient prognosis, and novel markers of potential relevance for molecular classification, prognosis and therapy of endometrial cancer were found.View this table:" @default.
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- W1451465362 date "2006-04-15" @default.
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- W1451465362 title "Gene expression profiles identify an aggressive phenotype in endometrial carcinoma" @default.
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