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- W1451491760 abstract "This chapter discusses the uricosuric drugs, with special reference to probenecid and sulfinpyrazone. Uricosuric drugs increase urinary uric acid excretion by inhibiting renal tubular reabsorption of uric acid, and thereby reduce the plasma urate concentration and enhance the renal clearance of uric acid. The compounds possessing authentic uricosuric properties are of diverse structure, with no apparent coninion coniponent, but virtually all are organic acids; a striking and inexplicable exception is zoxazolamine, a weak base yet one of the most potent of the uricosuric drugs. The uricosuria produced by these various agents really represents a net renal response, since the acidic uricosuric drugs are all secreted by the same “organic acid system” of renal tubular transport, in common with uric acid, and in the process may also competitively inhibit, to greater or lesser degree, the tubular secretion of uric acid. When there is a dual action on tubular reabsorption and secretion of uric acid, the net effect, whether it is to augment or to diminish urinary elimination of uric acid, varies with the nature of the drug, the dosage employed, and the species treated." @default.
- W1451491760 created "2016-06-24" @default.
- W1451491760 creator A5052109476 @default.
- W1451491760 date "1966-01-01" @default.
- W1451491760 modified "2023-10-07" @default.
- W1451491760 title "Uricosuric Drugs, with Special Reference to Probenecid and Sulfinpyrazone" @default.
- W1451491760 cites W100472394 @default.
- W1451491760 cites W125103791 @default.
- W1451491760 cites W1490610410 @default.
- W1451491760 cites W1497280552 @default.
- W1451491760 cites W1504321815 @default.
- W1451491760 cites W1506736168 @default.
- W1451491760 cites W1508730159 @default.
- W1451491760 cites W1558485391 @default.
- W1451491760 cites W1590920886 @default.
- W1451491760 cites W167786905 @default.
- W1451491760 cites W1846454258 @default.
- W1451491760 cites W186437974 @default.
- W1451491760 cites W1928764148 @default.
- W1451491760 cites W1963742916 @default.
- W1451491760 cites W1965092088 @default.
- W1451491760 cites W1966242104 @default.
- W1451491760 cites W1966860961 @default.
- W1451491760 cites W1967851586 @default.
- W1451491760 cites W1968328122 @default.
- W1451491760 cites W1968502690 @default.
- W1451491760 cites W1969343323 @default.
- W1451491760 cites W1969783245 @default.
- W1451491760 cites W1970164329 @default.
- W1451491760 cites W1970849507 @default.
- W1451491760 cites W1971501265 @default.
- W1451491760 cites W1972943356 @default.
- W1451491760 cites W1974024454 @default.
- W1451491760 cites W1974497126 @default.
- W1451491760 cites W1975144676 @default.
- W1451491760 cites W1975356706 @default.
- W1451491760 cites W1975613741 @default.
- W1451491760 cites W1976673583 @default.
- W1451491760 cites W1977073695 @default.
- W1451491760 cites W1978602701 @default.
- W1451491760 cites W1978788272 @default.
- W1451491760 cites W1979003751 @default.
- W1451491760 cites W1979047846 @default.
- W1451491760 cites W1979294129 @default.
- W1451491760 cites W1979357984 @default.
- W1451491760 cites W1980061683 @default.
- W1451491760 cites W1980237387 @default.
- W1451491760 cites W1982399519 @default.
- W1451491760 cites W1982513948 @default.
- W1451491760 cites W1982642955 @default.
- W1451491760 cites W1982897285 @default.
- W1451491760 cites W1983316495 @default.
- W1451491760 cites W1984121318 @default.
- W1451491760 cites W1984368902 @default.
- W1451491760 cites W1984474976 @default.
- W1451491760 cites W1984933675 @default.
- W1451491760 cites W1988301710 @default.
- W1451491760 cites W1988500568 @default.
- W1451491760 cites W1989099003 @default.
- W1451491760 cites W1989543215 @default.
- W1451491760 cites W1991234816 @default.
- W1451491760 cites W1991473086 @default.
- W1451491760 cites W1992346529 @default.
- W1451491760 cites W1993581127 @default.
- W1451491760 cites W1994733634 @default.
- W1451491760 cites W1994824319 @default.
- W1451491760 cites W1995311734 @default.
- W1451491760 cites W1995319076 @default.
- W1451491760 cites W1995723378 @default.
- W1451491760 cites W1995842983 @default.
- W1451491760 cites W1996225383 @default.
- W1451491760 cites W1997031824 @default.
- W1451491760 cites W1997838911 @default.
- W1451491760 cites W1998944035 @default.
- W1451491760 cites W1999178502 @default.
- W1451491760 cites W1999297920 @default.
- W1451491760 cites W2000069533 @default.
- W1451491760 cites W2001397253 @default.
- W1451491760 cites W2001510849 @default.
- W1451491760 cites W2002378895 @default.
- W1451491760 cites W2002459383 @default.
- W1451491760 cites W2003905053 @default.
- W1451491760 cites W2004163096 @default.
- W1451491760 cites W2004634799 @default.
- W1451491760 cites W2005165844 @default.
- W1451491760 cites W2005180392 @default.
- W1451491760 cites W2005186981 @default.
- W1451491760 cites W2005255350 @default.
- W1451491760 cites W2005426195 @default.
- W1451491760 cites W2005613012 @default.
- W1451491760 cites W2005617958 @default.
- W1451491760 cites W2005829833 @default.
- W1451491760 cites W2005865372 @default.
- W1451491760 cites W2006018289 @default.
- W1451491760 cites W2006564813 @default.
- W1451491760 cites W2006963479 @default.
- W1451491760 cites W2007114437 @default.
- W1451491760 cites W2007193184 @default.