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- W1451763902 abstract "Endocrine disrupting compounds (EDCs) are hypothesized to promote obesity and early puberty but their interactive effects with hormonally active diets are poorly understood. Here we assessed individual and combinatorial effects of soy diet or the isoflavone genistein (GEN; administered as the aglycone genistin GIN) with bisphenol A (BPA) on body weight, ingestive behavior and female puberal onset in Wistar rats. Soy-fed dams gained less weight during pregnancy and, although they consumed more than dams on a soy-free diet during lactation, did not become heavier. Their offspring (both sexes), however, became significantly heavier (more pronounced in males) pre-weaning. Soy also enhanced food intake and accelerated female pubertal onset in the offspring. Notably, pubertal onset was also advanced in females placed on soy diet at weaning. Males exposed to BPA plus soy diet, but not BPA alone, had lighter testes. BPA had no independent effects." @default.
- W1451763902 created "2016-06-24" @default.
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- W1451763902 creator A5080770984 @default.
- W1451763902 date "2015-12-01" @default.
- W1451763902 modified "2023-09-22" @default.
- W1451763902 title "Soy but not bisphenol A (BPA) or the phytoestrogen genistin alters developmental weight gain and food intake in pregnant rats and their offspring" @default.
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- W1451763902 doi "https://doi.org/10.1016/j.reprotox.2015.07.077" @default.
- W1451763902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4690759" @default.
- W1451763902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26216788" @default.
- W1451763902 hasPublicationYear "2015" @default.
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