Matches in SemOpenAlex for { <https://semopenalex.org/work/W1451995965> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W1451995965 endingPage "83" @default.
- W1451995965 startingPage "83" @default.
- W1451995965 abstract "Proc Amer Assoc Cancer Res, Volume 47, 2006357 Current evidence indicates that neoplastic nodules induced in liver of BN rats genetically resistant to hepatocarcinogenesis are not prone to evolve to hepatocellular carcinoma (HCC). Previous research showed cell cycle deregulation in neoplastic liver nodules and HCCs of susceptible F344 rats. Lower or no changes were found in BN rats, where overexpression of p16INK4a occurs. Here we show that BN rats subjected to diethylnitrosamine/2-acetylaminofluorene/partial hepatectomy treatment of “resistant-hepatocyte” protocol display higher number of glutathione-S-transferase 7-7(+) hepatocytes when compared to F344 rats, both during and at the end of 2-acetylaminofluorene treatment. However, DNA synthesis declines in BN but not in F344 rats after completion of promoting stimulus represented by reparative growth. Cell cycle inhibition by p16INK4A can be modulated by Cdc37-Hsp90 complex and Crm1 protein. The Cdc37- Hsp-90 complex protects Cdk4/6 from forming a complex with p16INK4A. Crm1 operates the cytoplasmic redistribution of E2f4, a transcription repressor acting as a downstream mediator of p16INK4A. We observed up-regulation of p16INK4A , Hsp90 , and Cdc37 genes, an increase in Cdc37-Cdk4 complexes, and a decrease in p16INK4A-Cdk4 complexes in preneoplastic liver, nodules and hepatocellular carcinomas of F344 rats. These parameters do not change significantly in BN rats. E2f4 is equally expressed in the lesions of both strains, but Crm1 expression and levels of E2f4-Crm1 complex are higher in F344 rats. Marked up-regulation of P16INK4A is associated with moderate overexpression of HSP90, CDC37, E2F4, and CRM1 in human HCCs with a better prognosis. In contrast, strong induction of HSP90, CDC37, and E2F4 is paralleled by P16INK4A down-regulation and high levels of HSP90-CDK4 and CDC37-CDK4 complexes in human HCCs with poorer prognosis. CDC37 down-regulation by small interfering RNA inhibits in vitro growth of HepG2 cells. In conclusion, our results underline the role of Hsp90/Cdc37 and E2f4/Crm1 systems in the acquisition of a susceptible or resistant phenotype. The results also suggest that protection by Cdc37 and Crm1 against growth restraint by P16INK4A influences the prognosis of human hepatocellular carcinoma." @default.
- W1451995965 created "2016-06-24" @default.
- W1451995965 creator A5001796204 @default.
- W1451995965 creator A5003859094 @default.
- W1451995965 creator A5016429110 @default.
- W1451995965 creator A5022713373 @default.
- W1451995965 creator A5053247747 @default.
- W1451995965 creator A5055851492 @default.
- W1451995965 creator A5086003708 @default.
- W1451995965 creator A5087039518 @default.
- W1451995965 creator A5087862269 @default.
- W1451995965 creator A5089236337 @default.
- W1451995965 creator A5091038323 @default.
- W1451995965 date "2006-04-15" @default.
- W1451995965 modified "2023-09-23" @default.
- W1451995965 title "Modulation of P16INK4A activity by Hsp90, Cdc37 and CRM1 influences the progression of preneoplastic lesions in rats with different predisposition to liver cancer and the prognosis of human hepatocellular carcinoma" @default.
- W1451995965 hasPublicationYear "2006" @default.
- W1451995965 type Work @default.
- W1451995965 sameAs 1451995965 @default.
- W1451995965 citedByCount "0" @default.
- W1451995965 crossrefType "journal-article" @default.
- W1451995965 hasAuthorship W1451995965A5001796204 @default.
- W1451995965 hasAuthorship W1451995965A5003859094 @default.
- W1451995965 hasAuthorship W1451995965A5016429110 @default.
- W1451995965 hasAuthorship W1451995965A5022713373 @default.
- W1451995965 hasAuthorship W1451995965A5053247747 @default.
- W1451995965 hasAuthorship W1451995965A5055851492 @default.
- W1451995965 hasAuthorship W1451995965A5086003708 @default.
- W1451995965 hasAuthorship W1451995965A5087039518 @default.
- W1451995965 hasAuthorship W1451995965A5087862269 @default.
- W1451995965 hasAuthorship W1451995965A5089236337 @default.
- W1451995965 hasAuthorship W1451995965A5091038323 @default.
- W1451995965 hasConcept C126322002 @default.
- W1451995965 hasConcept C202751555 @default.
- W1451995965 hasConcept C2776231280 @default.
- W1451995965 hasConcept C2778019345 @default.
- W1451995965 hasConcept C2779314089 @default.
- W1451995965 hasConcept C2779838395 @default.
- W1451995965 hasConcept C502942594 @default.
- W1451995965 hasConcept C54355233 @default.
- W1451995965 hasConcept C71924100 @default.
- W1451995965 hasConcept C86803240 @default.
- W1451995965 hasConcept C87644729 @default.
- W1451995965 hasConceptScore W1451995965C126322002 @default.
- W1451995965 hasConceptScore W1451995965C202751555 @default.
- W1451995965 hasConceptScore W1451995965C2776231280 @default.
- W1451995965 hasConceptScore W1451995965C2778019345 @default.
- W1451995965 hasConceptScore W1451995965C2779314089 @default.
- W1451995965 hasConceptScore W1451995965C2779838395 @default.
- W1451995965 hasConceptScore W1451995965C502942594 @default.
- W1451995965 hasConceptScore W1451995965C54355233 @default.
- W1451995965 hasConceptScore W1451995965C71924100 @default.
- W1451995965 hasConceptScore W1451995965C86803240 @default.
- W1451995965 hasConceptScore W1451995965C87644729 @default.
- W1451995965 hasLocation W14519959651 @default.
- W1451995965 hasOpenAccess W1451995965 @default.
- W1451995965 hasPrimaryLocation W14519959651 @default.
- W1451995965 hasRelatedWork W1964694561 @default.
- W1451995965 hasRelatedWork W1982023234 @default.
- W1451995965 hasRelatedWork W1992109206 @default.
- W1451995965 hasRelatedWork W1994579379 @default.
- W1451995965 hasRelatedWork W1999132652 @default.
- W1451995965 hasRelatedWork W2049539688 @default.
- W1451995965 hasRelatedWork W2051533821 @default.
- W1451995965 hasRelatedWork W2073891760 @default.
- W1451995965 hasRelatedWork W2076276382 @default.
- W1451995965 hasRelatedWork W2083404922 @default.
- W1451995965 hasRelatedWork W2114887449 @default.
- W1451995965 hasRelatedWork W2131491125 @default.
- W1451995965 hasRelatedWork W2132378802 @default.
- W1451995965 hasRelatedWork W2155067636 @default.
- W1451995965 hasRelatedWork W2164055600 @default.
- W1451995965 hasRelatedWork W2280873647 @default.
- W1451995965 hasRelatedWork W2314384238 @default.
- W1451995965 hasRelatedWork W2566530520 @default.
- W1451995965 hasRelatedWork W2635476643 @default.
- W1451995965 hasRelatedWork W2183373010 @default.
- W1451995965 hasVolume "66" @default.
- W1451995965 isParatext "false" @default.
- W1451995965 isRetracted "false" @default.
- W1451995965 magId "1451995965" @default.
- W1451995965 workType "article" @default.