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- W1452014513 abstract "This chapter presents an overview of the antiarrhythmic agents. β-adrenergic blocking agents and analogs possessing local anesthetic or direct nonspecific membrane action on the myocardium are the two types of agents that are discussed. β-adrenergic blocking agents antagonize the positive inotropic and chronotropic effects of catecholamines. Cardiac arrhythmias associated with excessive adrenergic stimulus-released endogenous catecholamines or sensitization of the heart by anesthetics or cardiac glycosides may effectively be treated by β-blockade. Some β-blockers also possess membrane or local anesthetic action and are effective against arrhythmias due to ischemia or cardiac glycoside toxicity as well. Dual-acting beta-blockers are effective against a variety of cardiac arrhythmias since they possess both β-blocking and local anesthetic activity. A major disadvantage in the use of β-blockers is their negative inotropic and chronotropic effects on the heart. While lidocaine and procaine amide are effective antiarrhythmics, lack of oral activity and toxicity has led to the development of newer analogs. Studies also reveal that cardiac glycosides have both a beneficial effect of improved conduction and an ability to cause arrhythmias." @default.
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- W1452014513 date "1971-01-01" @default.
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- W1452014513 title "Chapter 9. Antiarrhythmic Agents" @default.
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- W1452014513 doi "https://doi.org/10.1016/s0065-7743(08)60964-1" @default.
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