FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1452391417> ?p ?o ?g. }

• W1452391417 endingPage "1383" @default.
• W1452391417 startingPage "1383" @default.
• W1452391417 abstract "Renal failure is the most powerful predictor of death in decompensated cirrhosis. We conducted this prospective, observational, cohort study to determine the factors influencing hepatorenal syndrome (HRS) development, survival and determine predictors of response and outcome in terlipressin responders. Cirrhotic patients were diagnosed with AKI as per (IAC/ADQI - International Ascites Club/Acute Dialysis Quality Initiative) definition and evaluated as per the study protocol after taking written informed consent and applying inclusion exclusion criteria. The patients who received terlipressin were analysed for predictors of terlipressin response. Those patients with diagnosis of HRS were analysed for the factors influencing its development and survival. 395 consecutive cirrhotic patients with renal impairment defined as per protocol definitions were included. Out of these AKI patients HRS was seen in 85 patients (21.5%). Terlipressin was given to 162 patients, 72 (44%) patients responded to terlipressin as per the study definition. 90 (56%) patients were terlipressin non responders. HRS had the worst survival outcome, around 20% at 30 days and less than 10% at 90 days. Significantly worst survival was seen in terlipressin non responders at around 10% and less than 10% at 30 days and 90 days respectively as compared to terlipressin responders with 30 day survival around 50% and 90 day survival at around 20% respectively. Higher MELD score, low Serum albumin, presence of SBP and presence of hypotension with inotrope requirement were more significantly associated with HRS/ATN development whereas HRS mortality did not get affected with infection related parameters Longer duration of hospitalization, higher CTP & MELD score,male gender, presence of HE and hypotension with inotropic support requirement correlated significantly with response to terlipressin on univariate analysis. Presence of hypotension requiring inotropic support was the only factor on multivariate analysis to correlate with terlipressin non response. Development of HRS is associated with significantly reduced survival than other types of AKI in cirrhotics with especially dismal survival in terlipressin non responders. The terlipressin response rate in our cohort was 44%. Development of hypotension with inotropic requirement was the single most important predictor of terlipressin non response." @default.
• W1452391417 created "2016-06-24" @default.
• W1452391417 creator A5030518012 @default.
• W1452391417 creator A5030911667 @default.
• W1452391417 creator A5035683743 @default.
• W1452391417 creator A5046178403 @default.
• W1452391417 creator A5061245027 @default.
• W1452391417 creator A5069119884 @default.
• W1452391417 creator A5077769128 @default.
• W1452391417 creator A5079408290 @default.
• W1452391417 creator A5081124958 @default.
• W1452391417 creator A5089906185 @default.
• W1452391417 creator A5089979295 @default.
• W1452391417 date "2015-07-01" @default.
• W1452391417 modified "2023-10-16" @default.
• W1452391417 title "Predictors of Response and Outcome to Terlipressin in Patients With Hepatorenal Syndrome" @default.
• W1452391417 doi "https://doi.org/10.1016/j.cgh.2015.04.036" @default.
• W1452391417 hasPublicationYear "2015" @default.
• W1452391417 type Work @default.
• W1452391417 sameAs 1452391417 @default.
• W1452391417 citedByCount "1" @default.
• W1452391417 countsByYear W14523914172021 @default.
• W1452391417 crossrefType "journal-article" @default.
• W1452391417 hasAuthorship W1452391417A5030518012 @default.
• W1452391417 hasAuthorship W1452391417A5030911667 @default.
• W1452391417 hasAuthorship W1452391417A5035683743 @default.
• W1452391417 hasAuthorship W1452391417A5046178403 @default.
• W1452391417 hasAuthorship W1452391417A5061245027 @default.
• W1452391417 hasAuthorship W1452391417A5069119884 @default.
• W1452391417 hasAuthorship W1452391417A5077769128 @default.
• W1452391417 hasAuthorship W1452391417A5079408290 @default.
• W1452391417 hasAuthorship W1452391417A5081124958 @default.
• W1452391417 hasAuthorship W1452391417A5089906185 @default.
• W1452391417 hasAuthorship W1452391417A5089979295 @default.
• W1452391417 hasConcept C126322002 @default.
• W1452391417 hasConcept C2776988256 @default.
• W1452391417 hasConcept C2777214474 @default.
• W1452391417 hasConcept C2777364826 @default.
• W1452391417 hasConcept C2779393834 @default.
• W1452391417 hasConcept C2779541074 @default.
• W1452391417 hasConcept C2779978075 @default.
• W1452391417 hasConcept C2780496750 @default.
• W1452391417 hasConcept C71924100 @default.
• W1452391417 hasConcept C90924648 @default.
• W1452391417 hasConceptScore W1452391417C126322002 @default.
• W1452391417 hasConceptScore W1452391417C2776988256 @default.
• W1452391417 hasConceptScore W1452391417C2777214474 @default.
• W1452391417 hasConceptScore W1452391417C2777364826 @default.
• W1452391417 hasConceptScore W1452391417C2779393834 @default.
• W1452391417 hasConceptScore W1452391417C2779541074 @default.
• W1452391417 hasConceptScore W1452391417C2779978075 @default.
• W1452391417 hasConceptScore W1452391417C2780496750 @default.
• W1452391417 hasConceptScore W1452391417C71924100 @default.
• W1452391417 hasConceptScore W1452391417C90924648 @default.
• W1452391417 hasIssue "7" @default.
• W1452391417 hasLocation W14523914171 @default.
• W1452391417 hasOpenAccess W1452391417 @default.
• W1452391417 hasPrimaryLocation W14523914171 @default.
• W1452391417 hasRelatedWork W1588306867 @default.
• W1452391417 hasRelatedWork W2036652612 @default.
• W1452391417 hasRelatedWork W2137466533 @default.
• W1452391417 hasRelatedWork W2207296767 @default.
• W1452391417 hasRelatedWork W2338756788 @default.
• W1452391417 hasRelatedWork W2405781721 @default.
• W1452391417 hasRelatedWork W2443331516 @default.
• W1452391417 hasRelatedWork W2803936932 @default.
• W1452391417 hasRelatedWork W3134518824 @default.
• W1452391417 hasRelatedWork W2922528030 @default.
• W1452391417 hasVolume "13" @default.
• W1452391417 isParatext "false" @default.
• W1452391417 isRetracted "false" @default.
• W1452391417 magId "1452391417" @default.
• W1452391417 workType "article" @default.