Matches in SemOpenAlex for { <https://semopenalex.org/work/W1452893412> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W1452893412 endingPage "1142" @default.
- W1452893412 startingPage "1141" @default.
- W1452893412 abstract "Oxidative stress plays a vital role in the pathogenesis of neurodegenerativediseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and Parkinson’s disease. The recent excellent article by Kamat et al. published in Journal of Alzheimer’s Disease [1] provided a comprehensive review on the current status of antioxidant therapy for neurodegenerative diseases and analyzed the disappointing clinical trials. In fact, in recent years failures of antioxidants in clinic trials for many other diseases caused by oxidative stress, such as cancer and cardiovascular diseases, have been widely reported [2,3]. Thus, it is of significance to explore the potential reasons why antioxidants have failed in clinical trials. We agree well with Kamat et al.’s opinion that the negative clinical trials do not disprove the pathogenic role of oxidative stress in neurodegenerative diseases [1]. However, besides the possible reasons provided by Kamat et al. [1], we propose some more basic factors, including the intrinsic features of antioxidants and heterogeneity of biological" @default.
- W1452893412 created "2016-06-24" @default.
- W1452893412 creator A5008806398 @default.
- W1452893412 creator A5015212924 @default.
- W1452893412 date "2010-03-11" @default.
- W1452893412 modified "2023-10-18" @default.
- W1452893412 title "Insights into the Disappointing Clinical Trials of Antioxidants in Neurodegenerative Diseases" @default.
- W1452893412 cites W1678920698 @default.
- W1452893412 cites W1768446746 @default.
- W1452893412 cites W1979911088 @default.
- W1452893412 cites W2000699455 @default.
- W1452893412 cites W2005006344 @default.
- W1452893412 cites W2050096066 @default.
- W1452893412 cites W2057523433 @default.
- W1452893412 cites W2070119736 @default.
- W1452893412 cites W2083769086 @default.
- W1452893412 cites W2105234557 @default.
- W1452893412 cites W2121075670 @default.
- W1452893412 cites W2125300901 @default.
- W1452893412 cites W2147812763 @default.
- W1452893412 cites W2159879659 @default.
- W1452893412 doi "https://doi.org/10.3233/jad-2010-1307" @default.
- W1452893412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20308779" @default.
- W1452893412 hasPublicationYear "2010" @default.
- W1452893412 type Work @default.
- W1452893412 sameAs 1452893412 @default.
- W1452893412 citedByCount "9" @default.
- W1452893412 countsByYear W14528934122012 @default.
- W1452893412 countsByYear W14528934122013 @default.
- W1452893412 countsByYear W14528934122014 @default.
- W1452893412 countsByYear W14528934122015 @default.
- W1452893412 countsByYear W14528934122019 @default.
- W1452893412 countsByYear W14528934122023 @default.
- W1452893412 crossrefType "journal-article" @default.
- W1452893412 hasAuthorship W1452893412A5008806398 @default.
- W1452893412 hasAuthorship W1452893412A5015212924 @default.
- W1452893412 hasConcept C126322002 @default.
- W1452893412 hasConcept C15744967 @default.
- W1452893412 hasConcept C169760540 @default.
- W1452893412 hasConcept C177713679 @default.
- W1452893412 hasConcept C535046627 @default.
- W1452893412 hasConcept C71924100 @default.
- W1452893412 hasConceptScore W1452893412C126322002 @default.
- W1452893412 hasConceptScore W1452893412C15744967 @default.
- W1452893412 hasConceptScore W1452893412C169760540 @default.
- W1452893412 hasConceptScore W1452893412C177713679 @default.
- W1452893412 hasConceptScore W1452893412C535046627 @default.
- W1452893412 hasConceptScore W1452893412C71924100 @default.
- W1452893412 hasIssue "4" @default.
- W1452893412 hasLocation W14528934121 @default.
- W1452893412 hasLocation W14528934122 @default.
- W1452893412 hasOpenAccess W1452893412 @default.
- W1452893412 hasPrimaryLocation W14528934121 @default.
- W1452893412 hasRelatedWork W1977867207 @default.
- W1452893412 hasRelatedWork W2008247344 @default.
- W1452893412 hasRelatedWork W2032098698 @default.
- W1452893412 hasRelatedWork W2052303540 @default.
- W1452893412 hasRelatedWork W2085862598 @default.
- W1452893412 hasRelatedWork W2136006960 @default.
- W1452893412 hasRelatedWork W2566747388 @default.
- W1452893412 hasRelatedWork W2748952813 @default.
- W1452893412 hasRelatedWork W2899084033 @default.
- W1452893412 hasRelatedWork W4252371801 @default.
- W1452893412 hasVolume "19" @default.
- W1452893412 isParatext "false" @default.
- W1452893412 isRetracted "false" @default.
- W1452893412 magId "1452893412" @default.
- W1452893412 workType "article" @default.