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• W145291007 abstract "Research Article1 August 1984free access The molecular basis of alpha-thalassaemia in Thailand. P. Winichagoon P. Winichagoon Search for more papers by this author D.R. Higgs D.R. Higgs Search for more papers by this author S.E. Goodbourn S.E. Goodbourn Search for more papers by this author J.B. Clegg J.B. Clegg Search for more papers by this author D.J. Weatherall D.J. Weatherall Search for more papers by this author P. Wasi P. Wasi Search for more papers by this author P. Winichagoon P. Winichagoon Search for more papers by this author D.R. Higgs D.R. Higgs Search for more papers by this author S.E. Goodbourn S.E. Goodbourn Search for more papers by this author J.B. Clegg J.B. Clegg Search for more papers by this author D.J. Weatherall D.J. Weatherall Search for more papers by this author P. Wasi P. Wasi Search for more papers by this author Author Information P. Winichagoon, D.R. Higgs, S.E. Goodbourn, J.B. Clegg, D.J. Weatherall and P. Wasi The EMBO Journal (1984)3:1813-1818https://doi.org/10.1002/j.1460-2075.1984.tb02051.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The molecular basis of alpha-thalassaemia has been established in 48 Thai subjects with Hb H disease and 15 with the Hb Bart's hydrops fetalis syndrome. This study has shown that in this population there are at least 18 different types of chromosome carrying seven independent alpha-thalassaemia mutations one of which is a novel deletion removing the entire alpha-globin gene complex. Although there are a limited number of alpha-thalassaemia determinants in the Thai population, there is a remarkable degree of variation in the genetic markers which flank them. These markers may be of value in establishing the evolutionary history of the alpha-thalassaemias. Previous ArticleNext Article Volume 3Issue 81 August 1984In this issue RelatedDetailsLoading ..." @default.
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