FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W145295610> ?p ?o ?g. }

• W145295610 abstract "We have investigated whether the pathogenesis of spontaneous generalized non-convulsive seizures in rats with genetic absence epilepsy is due to an increase in the brain levels of gamma-hydroxybutyric acid (GHB) or in the rate of its synthesis. Concentrations of GHB or of its precursor gamma-butyrolactone (GBL) were measured with a new GC/MS technique which allows the simultaneous assessment of GHB and GBL. The rate of GHB synthesis was estimated from the increase in GHB levels after inhibition of its catabolism with valproate. The results of this study do not indicate significant differences in GHB or GBL levels, or in their rates of synthesis in rats showing spike-and-wave discharges (SWD) as compared to rats without SWD. Binding data indicate that GHB, but not GBL, has a selective, although weak affinity for GABAB receptors (IC50 = 150 microM). Similar IC50 values were observed in membranes prepared from rats showing SWD and from control rats. The average GHB brain levels of 2.12 +/- 0.23 nmol/g measured in the cortex and of 4.28 +/- 0.90 nmol/g in the thalamus are much lower than the concentrations necessary to occupy a major part of the GABAB receptors. It is unlikely that local accumulations of GHB reach concentrations 30-70-fold higher than the average brain levels. After injection of 3.5 mmol/kg GBL, a dose sufficient to induce SWD, brain concentrations reach 240 +/- 31 nmol/g (Snead, 1991) and GHB could thus stimulate the GABAB receptor. Like the selective and potent GABAB receptor agonist R(-)-baclofen, GHB causes a dose-related decrease in cerebellar cGMP. This decrease and the increase in SWD caused by R(-)-baclofen were completely blocked by the selective and potent GABAB receptor antagonist CGP 35348, whereas only the increase in the duration of SWD induced by GHB was totally antagonized by CGP 35348. The decrease in cerebellar cGMP levels elicited by GHB was only partially antagonized by CGP 35348. These findings suggest that all effects of R(-)-baclofen are mediated by the GABAB receptor, whereas only the induction of SWD by GHB is dependent on GABAB receptor mediation, the decrease in cGMP being only partially so. Taken together with the observations of Marescaux et al. (1992), these results indicate that GABAB receptors are of primary importance in experimental absence epilepsy and that GABAB receptor antagonists may represent a new class of anti-absence drugs." @default.
• W145295610 created "2016-06-24" @default.
• W145295610 creator A5005182399 @default.
• W145295610 creator A5005186185 @default.
• W145295610 creator A5021166714 @default.
• W145295610 creator A5036919122 @default.
• W145295610 creator A5043854185 @default.
• W145295610 creator A5047125398 @default.
• W145295610 creator A5052216135 @default.
• W145295610 creator A5054899787 @default.
• W145295610 creator A5068669104 @default.
• W145295610 date "1992-01-01" @default.
• W145295610 modified "2023-09-25" @default.
• W145295610 title "Experimental absence seizures: potential role of γ-hydroxybutyric acid and GABAB receptors" @default.
• W145295610 cites W10516741 @default.
• W145295610 cites W1545913212 @default.
• W145295610 cites W1603917012 @default.
• W145295610 cites W1684853394 @default.
• W145295610 cites W1972649872 @default.
• W145295610 cites W1976655932 @default.
• W145295610 cites W1977880829 @default.
• W145295610 cites W1988705766 @default.
• W145295610 cites W1993405721 @default.
• W145295610 cites W1995316734 @default.
• W145295610 cites W2002310592 @default.
• W145295610 cites W2002956716 @default.
• W145295610 cites W2012691307 @default.
• W145295610 cites W2015743538 @default.
• W145295610 cites W2018430265 @default.
• W145295610 cites W2022890204 @default.
• W145295610 cites W2028569155 @default.
• W145295610 cites W2029837689 @default.
• W145295610 cites W2032310869 @default.
• W145295610 cites W2039341631 @default.
• W145295610 cites W2041058405 @default.
• W145295610 cites W2042076054 @default.
• W145295610 cites W2054951528 @default.
• W145295610 cites W2056108921 @default.
• W145295610 cites W2058419958 @default.
• W145295610 cites W2058586108 @default.
• W145295610 cites W2062604521 @default.
• W145295610 cites W2063012753 @default.
• W145295610 cites W2066628109 @default.
• W145295610 cites W2066991732 @default.
• W145295610 cites W2067267876 @default.
• W145295610 cites W2069146882 @default.
• W145295610 cites W2072058826 @default.
• W145295610 cites W2074162571 @default.
• W145295610 cites W2084741382 @default.
• W145295610 cites W2088616807 @default.
• W145295610 cites W2115250531 @default.
• W145295610 cites W2121297747 @default.
• W145295610 cites W2125329047 @default.
• W145295610 cites W2136514333 @default.
• W145295610 cites W2139578829 @default.
• W145295610 cites W2145321763 @default.
• W145295610 cites W2157336825 @default.
• W145295610 cites W2164566170 @default.
• W145295610 cites W2331856291 @default.
• W145295610 cites W2418322704 @default.
• W145295610 cites W345756771 @default.
• W145295610 cites W4238961163 @default.
• W145295610 doi "https://doi.org/10.1007/978-3-7091-9206-1_11" @default.
• W145295610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1324978" @default.
• W145295610 hasPublicationYear "1992" @default.
• W145295610 type Work @default.
• W145295610 sameAs 145295610 @default.
• W145295610 citedByCount "29" @default.
• W145295610 countsByYear W1452956102012 @default.
• W145295610 countsByYear W1452956102019 @default.
• W145295610 countsByYear W1452956102021 @default.
• W145295610 crossrefType "book-chapter" @default.
• W145295610 hasAuthorship W145295610A5005182399 @default.
• W145295610 hasAuthorship W145295610A5005186185 @default.
• W145295610 hasAuthorship W145295610A5021166714 @default.
• W145295610 hasAuthorship W145295610A5036919122 @default.
• W145295610 hasAuthorship W145295610A5043854185 @default.
• W145295610 hasAuthorship W145295610A5047125398 @default.
• W145295610 hasAuthorship W145295610A5052216135 @default.
• W145295610 hasAuthorship W145295610A5054899787 @default.
• W145295610 hasAuthorship W145295610A5068669104 @default.
• W145295610 hasConcept C101027131 @default.
• W145295610 hasConcept C126322002 @default.
• W145295610 hasConcept C134018914 @default.
• W145295610 hasConcept C168258287 @default.
• W145295610 hasConcept C169760540 @default.
• W145295610 hasConcept C170493617 @default.
• W145295610 hasConcept C185592680 @default.
• W145295610 hasConcept C2778186239 @default.
• W145295610 hasConcept C55493867 @default.
• W145295610 hasConcept C62231903 @default.
• W145295610 hasConcept C71924100 @default.
• W145295610 hasConcept C86803240 @default.
• W145295610 hasConcept C96942376 @default.
• W145295610 hasConcept C98274493 @default.
• W145295610 hasConceptScore W145295610C101027131 @default.
• W145295610 hasConceptScore W145295610C126322002 @default.
• W145295610 hasConceptScore W145295610C134018914 @default.
• W145295610 hasConceptScore W145295610C168258287 @default.
• W145295610 hasConceptScore W145295610C169760540 @default.

• next